- CEO
- Richard Orr
- Full Time Employees
- 6
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 100 Pine Street San Francisco CA United States of America 94111
- IPO Date
- Dec 18, 1998
- Business
- Adynxx Inc (ADYX) is a clinical-stage biopharmaceutical company that develops and commercializes transcription factor decoy technologies for treating pain and inflammatory diseases; its AYX platform includes brivoligide (AYX1), an EGR1 transcription factor decoy in Phase II for reducing postoperative pain following surgeries such as total knee arthroplasty and mastectomy, and AYX2, a preclinical candidate for focal chronic pain including neuropathic and inflammatory types; the platform targets coordinated pathologic gene expression with non-opioid, disease-modifying therapeutics administered intrathecally as single doses. Founded in 2007 and headquartered in San Francisco, California, the company operates in the biotechnology sector, focusing on unmet needs in acute and chronic pain management for surgical patients at high risk of prolonged pain and opioid dependence; it targets U.S. markets with applications across multiple pain syndromes and collaborates on AI-driven discoveries for conditions like endometriosis. Adynxx completed a reverse merger with Alliqua BioMedical in May 2019, becoming Nasdaq-listed under its current name with former Adynxx holders owning 86% of the combined entity and shifting leadership to San Francisco; it secured a $5.7 million NIH grant from NIDA in 2019 for brivoligide's Phase II mastectomy study, with potential additional $9 million for Phase III; earlier, it closed a $16 million Series B financing led by TPG Biotech and received MTS Partners advisory for the Alliqua merger.