Agios Pharmaceuticals, Inc.

Agios Pharmaceuticals, Inc.

AGIO
Agios Pharmaceuticals, Inc.US flagNASDAQ Global Select
37.81
USD
-2.25
- -
2.25BMarket Cap
2013 Y
2014 Y
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
1.66
1.94
1.58
1.79
0.92
1.64
- -
- -
- -
0.26
0.48
0.64
0.93
1.13
Basic EPS, GAAP
-2.83
-1.59
-3.15
-5.07
-6.75
-6.03
-6.86
-4.74
26.55
-4.23
-6.33
11.86
-7.12
-7.25
Free Cash Flow per Basic Share
-3.74
-1.83
-2.59
0.73
-6.22
-5.42
-6.38
-4.42
-6.83
-5.74
-5.65
-6.89
-6.68
-6.6
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
-7.36
-4.96
-7.6
-12.35
-17.13
-19.24
-25.27
-26.72
-3.95
-8.59
-14.78
-2.62
-9.69
-13.77
Tangible Book Value per Share
8.53
12.6
9.22
9.16
8.06
11.97
10.68
5.79
21.37
20.09
14.57
27.13
20.58
19.03
Basic Weighted Avg Shares
15
34
37
39
47
57
60
69
60
55
56
57
58
58
Sales/Revenue/Turnover
26
65
59
70
43
94
- -
- -
- -
14
27
36
54
66
Operating Margin (%)
-152.2
-82.83
-200.78
-287.57
-745.84
-384.03
- -
- -
- -
-2,732.07
-1,459.52
-1,166.47
-873.87
-719.97
Depreciation Expense
1
1
3
6
6
7
8
10
9
9
7
6
5
5
Net Income, GAAP
-39
-54
-118
-198
-315
-346
-411
-327
1,605
-232
-352
674
-413
-423
Effective Tax Rate (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
6.16
- -
- -
Profit Margin (%)
-154.25
-81.86
-199.14
-283.97
-731.6
-366.61
- -
- -
- -
-1,627.82
-1,312.63
1,845.92
-764.01
-639.84
Working Capital
133
298
284
471
350
520
519
542
1,004
770
766
884
860
776
LT Debt
- -
- -
- -
- -
- -
- -
107
98
86
72
57
40
22
17
Total Equity
131
424
345
359
376
688
641
400
1,292
1,101
811
1,541
1,193
1,109
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
-32.19
- -
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
-159.95
- -
- -
Return on Common Equity (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -

Capital Structure

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
ST Debt
18
18
- -
LT Borrowings
- -
- -
- -
LT Finance Leases
27
22
17
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
58
58
59
Market Capitalization
2,322
1,575
1,972

Working Capital

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
Total Current Assets
1,033
942
835
Cash, Cash Equivalents & STI
953
854
114
Accounts Receivable, Net
5
11
16
Inventories
32
33
35
Total Current Liabilities
75
82
59
Payables & Accruals
37
37
- -
ST Debt
18
18
- -
Deferred Revenue
- -
- -
- -

Growth Rates

FRC

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
29.7%
49.94%
-22.57%
Free Cash Flow
-119.63%
7.01%
-1.08%
Net Income, GAAP
-96.98%
-221.07%
-161.27%
Sales/Revenue/Turnover
- -
- -
48.03%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
8
9
9
11
36
2025
9
12
13
20
54
2026
21
- -
- -
- -
- -

Quarterly Earnings Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-1.45
-1.69
16.65
- -
11.86
2025
-1.55
-1.93
-1.78
- -
-7.12
2026
-1.69
- -
- -
- -
- -

Quarterly Dividends Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

APIChatGPT
CEO
Brian Goff
Full Time Employees
540
Sector
Healthcare
Industry
Biotechnology
Address
88 Sidney Street Cambridge MA United States of America 02139-4169
IPO Date
Jul 24, 2013
Website
agios.com
Business
Agios Pharmaceuticals, Inc. is a biopharmaceutical company focused on discovering and developing transformative therapies primarily in the field of cellular metabolism, with a near-term emphasis on rare diseases such as hemolytic and acquired anemias. Founded in 2008 and headquartered in Cambridge, Massachusetts, Agios develops precision medicines including its flagship product, Pyrukynd (mitapivat), an oral activator of pyruvate kinase enzymes targeting hemolytic anemias such as pyruvate kinase deficiency and sickle cell disease. Its product portfolio also involves investigational candidates like tebapivat, a next-generation PK activator, and AG-236, aimed at addressing broader metabolic and hematologic disorders. The company’s offerings encompass small-molecule drugs and supportive patient services programs like myAgios to facilitate access and treatment adherence. Recent major developments include the positive results from the ACTIVATE-Kids Phase 3 study demonstrating the efficacy of mitapivat in pediatric patients with pyruvate kinase deficiency, establishing a pathway for pediatric label expansion. Agios is preparing for the U.S. commercial launch of Pyrukynd in multiple hemolytic anemia indications including sickle cell disease and thalassemia in 2026, supported by increased commercial infrastructure and headcount expansion. The company is advancing pipeline diversification with an IND filing planned for mid-2025 for AG-236 and Phase 2 trials for tebapivat in sickle cell disease, reinforcing its strategic objective to treat a broad spectrum of rare blood disorders through oral, disease-modifying therapies. Agios also concentrates on expanding its research into cancer metabolism as a complementary segment. Agios Pharmaceuticals operates primarily in the United States with its products addressing unmet needs in the rare genetic disease market and hematology segments. It leverages advanced technologies in metabolic pathway targeting, small molecule drug discovery, and clinical development. The company’s strategic alliances, regulatory progress, and patient-centric commercialization programs position it as a leader in the transformative rare disease therapy space. Its founding scientific focus on cellular metabolism continues to drive innovation across both rare hematologic diseases and oncology therapeutic areas. This comprehensive portfolio and recent clinical and commercial advances underline Agios’s commitment to providing long-term, disease-modifying treatments for patients with rare metabolic diseases and blood disorders.

Company News

APIChatGPT
  • Agios Reports Neutral Sickle Cell Data, Decides To Stop Development

  • Agios Pharma to discontinue sickle cell disease treatment development

  • Agios Provides Update on Phase 2 Trial of Tebapivat in Sickle Cell Disease

  • Here's Why Shares in Novo Nordisk Rival, Agios Pharmaceutical, Soared This Week

  • AGIO's Filing for Mitapivat in SCD Gets FDA's Priority Tag, Stock Up

  • Strength Seen in Agios Pharmaceuticals (AGIO): Can Its 17.7% Jump Turn into More Strength?

  • Here's Why Agios Pharmaceuticals Stock Soared Today (Hint: It's FDA-Related)

  • Why This Novo Nordisk Rival Just Soared Near A Profit-Taking Zone

  • U.S. FDA Grants Priority Review to Agios' sNDA for Mitapivat in Sickle Cell Disease

  • Agios to Host Second Quarter 2026 Financial Results Conference Call and Webcast on July 30 at 8:00 a.m. ET

  • AGIO Stock Surges 35% in Six Months: What's Driving It?

  • Agios Pharmaceuticals Touts Mitapivat Gains Despite Sickle Cell Pain Miss

  • Agios Pharmaceuticals, Inc. (AGIO) Discusses New Data and Strategic Expansion in Rare Hematology at EHA Investor Event Transcript

  • Agios Showcases RISE UP Phase 3 Results at EHA 2026 Plenary Session Reinforcing Strong Anti-Hemolytic Profile of Mitapivat in Sickle Cell Disease

  • AGIO Secures Global Rights to Late-Stage Rare Blood Disorder Candidate

  • Agios Pharmaceuticals, Inc. (AGIO) Discusses Global License Agreement for Cevidoplenib and Strategic Expansion in Rare Hematology Transcript

  • Agios Pharmaceuticals licenses global rights to Oscotec's SYK inhibitor cevidoplenib

  • AGIO Halts Tebapivat Development in Myelodysplastic Syndromes

  • Agios Enters Exclusive Global License Agreement with Oscotec to Develop and Commercialize Next-Generation SYK Inhibitor Cevidoplenib

  • Why Is Agios Pharmaceuticals (AGIO) Up 8.6% Since Last Earnings Report?