- CEO
- Hermann Luebbert
- Full Time Employees
- 92
- Sector
- Healthcare
- Industry
- Drug Manufacturers - Specialty & Generic
- Address
- 120 Presidential Way Woburn DE United States of America 01801
- IPO Date
- Oct 29, 2021
- Business
- Biofrontera Inc. (Nasdaq: BFRI, BFRIW) is a U.S.-based biopharmaceutical company that commercializes pharmaceutical products for the treatment of dermatological conditions, with a focus on photodynamic therapy (PDT) and topical antibiotics; its core offerings include Ameluz (aminolevulinic acid hydrochloride gel, 10%), used in combination with the RhodoLED lamp series for the lesion-directed and field-directed treatment of mild-to-moderate actinic keratosis on the face and scalp, as well as Xepi (ozenoxacin cream, 1%), a topical non-fluorinated quinolone for the treatment of impetigo. The company, founded in 2015 and headquartered in Woburn, Massachusetts, operates primarily in the United States, targeting dermatologists and healthcare providers for patients with pre-cancerous skin lesions and bacterial skin infections. In 2025, Biofrontera completed a major restructuring of its relationship with former parent Biofrontera AG, acquiring full U.S. rights, New Drug Application, intellectual property, and patents for Ameluz and RhodoLED, supported by $11 million in financing that reduces royalty payments to 12-15% of U.S. net sales from prior levels of 25-35%; it also divested Xepi, received FDA Orange Book listing for a propylene glycol-free Ameluz formulation with patent protection to 2043, completed patient enrollment in Phase 3 trials for Ameluz-PDT on actinic keratoses of the extremities, neck, and trunk, and achieved key milestones in Phase 3 studies for superficial basal cell carcinoma and Phase 2b for acne vulgaris.