bluebird bio, Inc.
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- Bluebird bio, Inc., operating within the biotechnology sector, is dedicated to the research, development, and commercialization of potentially curative gene therapies for severe genetic conditions. Its portfolio includes three approved, one-time ex-vivo gene therapies: Zynteglo (betibeglogene autotemcel) for transfusion-dependent beta-thalassemia in adult and pediatric patients; Skysona (elivaldogene autotemcel), approved to slow the progression of neurological dysfunction in boys aged 4-17 with early, active cerebral adrenoleukodystrophy, though the FDA is currently investigating reports of hematologic malignancies associated with this therapy; and Lyfgenia (lovotibeglogene autotemcel), cleared for individuals 12 years and older with sickle cell disease who have a history of vaso-occlusive events, which carries a boxed warning regarding the potential risk for blood cancers. The company emphasizes expanding patient access through a network of qualified treatment centers and conducts long-term follow-up studies to assess the durability and safety of its treatments. In a pivotal development, bluebird bio transitioned to a privately-held entity in June 2025, following its acquisition by investment funds managed by The Carlyle Group and SK Capital Partners. This strategic move aims to infuse significant capital and leadership to accelerate the commercial scaling and availability of its approved gene therapies for beta-thalassemia, sickle cell disease, and cerebral adrenoleukodystrophy. The company was originally founded in 1992 as Genetix Pharmaceuticals, Inc., changing its name to bluebird bio, Inc. in September 2010, and is now headquartered in Somerville, Massachusetts.
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