- CEO
- Davide Ruggero
- Full Time Employees
- 14
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 142 North Cedros Avenue Solana Beach DE United States of America 92075
- IPO Date
- Mar 1, 2021
- Business
- eFFECTOR Therapeutics, Inc. (EFTRW) is a clinical-stage biopharmaceutical company that develops selective translation regulator inhibitors for oncology indications; tomivosertib, an oral small-molecule inhibitor of MNK1/2 evaluated in a Phase 2b trial combined with pembrolizumab for metastatic non-small cell lung cancer; zotatifin, a small-molecule inhibitor of eIF4A advanced in Phase 2a expansion cohorts for biomarker-positive solid tumors including ER+ breast cancer and KRAS-mutant NSCLC, and in an investigator-sponsored Phase 2 trial with abemaciclib and letrozole for ER+ endometrial cancer and low-grade serous ovarian cancer via collaboration with Dana-Farber Cancer Institute; plus preclinical inhibitors of eIF4E under a global research collaboration and license agreement with Pfizer Inc. that provided $15 million upfront and potential milestones up to $492 million. Founded in 2012 and formerly headquartered in Solana Beach, California, with a recent address at 124 Washington Street, Ste. 101, Foxboro, MA 02035, the company pioneered oncology therapeutics targeting the eIF4F complex to modulate mRNA translation in cancer pathways like PI3K-AKT and RAS-MEK. In June 2024, following disappointing Phase 2b results for tomivosertib in frontline NSCLC that halted its development, eFFECTOR initiated a wind-down of operations including termination of all employees, appointed liquidation specialist Craig R. Jalbert as CEO, President, Treasurer, Secretary, and sole board member, pursued strategic alternatives for its pipeline programs, voluntarily requested delisting from Nasdaq due to non-compliance, and ceased active business activities with its website confirming the company is no longer operating.