Evelo Biosciences, Inc.
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- Evelo Biosciences, Inc. (EVLO) is a clinical-stage biotechnology company that discovers and develops oral medicines acting on immune cells in the small intestine to achieve systemic effects in treating inflammatory diseases and oncology indications; its core products include EDP1815, a whole-microbe candidate that completed Phase 2 trials in mild-to-moderate psoriasis and advanced into Phase 2 for atopic dermatitis, EDP2939, a next-generation extracellular vesicle product that initiated Phase 2 dosing in moderate psoriasis in 2023, EDP1867, a Veillonella parvula-based preparation in Phase 1b for inflammatory conditions, and EDP1908, an oncology-focused extracellular vesicle candidate progressing toward first-in-human studies. Founded in 2015 by Flagship Pioneering and headquartered in Cambridge, Massachusetts, the company operates primarily in the United States with a focus on the small intestinal axis (SINTAX) platform for modulating systemic immunity, inflammation, and metabolism without broad immunosuppression. Recent developments include a $25.5 million private placement in July 2023 led by Flagship Pioneering to fund the EDP2939 Phase 2a psoriasis trial readout and debt reduction, followed by a $79.2 million registered direct offering in late 2023 to advance EDP1815 registration trials in psoriasis and atopic dermatitis while progressing EDP2939; however, October 2023 top-line Phase 2 results for EDP2939 missed the primary endpoint, prompting cessation of its development, workforce reductions, and a strategic review for partnerships on EDP1815 and the SINTAX platform. As of late 2025, Evelo trades on OTC markets at minimal valuation amid ongoing pursuit of strategic alternatives.
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