Structure Therapeutics Inc.
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- Structure Therapeutics Inc. (NASDAQ:GPCR) is a clinical-stage biopharmaceutical company that develops novel oral small molecule therapeutics targeting G-protein coupled receptors (GPCRs) for chronic diseases with unmet medical needs, including obesity, type 2 diabetes, pulmonary fibrosis, and cardiopulmonary conditions; its lead candidate, aleniglipron (GSBR-1290), is an oral glucagon-like peptide-1 receptor (GLP-1R) agonist in Phase 2b trials (ACCESS and ACCESS II) for obesity and overweight with topline data expected by year-end 2025; additional pipeline assets include ACCG-2671 and ACCG-3535, oral amylin receptor agonists in IND-enabling studies and preclinical development for obesity with Phase 1 initiation planned by late 2025, ANPA-0073, an oral apelin receptor (APJR) agonist phase 2-ready for muscle-sparing weight loss, LTSE-2578, a lysophosphatidic acid 1 receptor (LPA1R) antagonist that completed Phase 1 for idiopathic pulmonary fibrosis, discovery programs modulating glucose-dependent insulinotropic polypeptide receptor (GIPR) with agonist, dual GLP-1R/GIPR agonist and antagonist candidates for obesity, and glucagon receptor (GCGR) program with agonist and dual GLP-1R/GCGR agonist hits; the company leverages structure-based drug discovery, computational chemistry, and structural biology platforms to optimize binding and pharmacokinetics for metabolic, inflammatory, and cardiopulmonary disorders. Founded in 2016 and formerly known as ShouTi Inc., Structure Therapeutics is headquartered in South San Francisco, California, with operations in the United States and China targeting global patient populations. Recent developments include completion of enrollment in aleniglipron Phase 2b obesity studies, announcement of three additional aleniglipron clinical studies for competitive positioning, advancement of oral amylin programs, asset sale of a program to Exelixis generating $10 million upfront with $5.2 million received, $547 million in financing secured in 2024, and a strengthened cash position of $883.5 million as of year-end 2024 funding operations through 2027.
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Structure Therapeutics Inc. (GPCR) Presents at Goldman Sachs 47th Annual Global Healthcare Conference 2026 Transcript
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