Galera Therapeutics, Inc.
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- Galera Therapeutics, Inc. (GRTX) is a clinical-stage biopharmaceutical company focused on developing small molecule therapeutics targeting cancer vulnerabilities in tumor cells, immune cells, and the tumor microenvironment, including superoxide dismutase (SOD) mimetics and nitric oxide synthase (NOS) inhibitors. The company offers a pipeline featuring tilarginine, a pan-NOS inhibitor in Phase 1/2 trials combined with standard-of-care nab-paclitaxel and alpelisib for metaplastic breast cancer and refractory triple-negative breast cancer; avasopasem manganese, a SOD mimetic previously studied for radiotherapy-induced toxicities in head and neck and lung cancer patients and now planned for a Phase 1b/2 trial in hormone receptor-positive/HER2-negative advanced breast cancer starting in the first half of 2025; and rucosopasem, another SOD mimetic. Founded in 2012 and headquartered in Malvern, Pennsylvania, Galera operates primarily in the United States with academic partnerships including the I-SPY 2 network and NCI grants targeting patients with treatment-resistant advanced breast cancer subtypes. Recent strategic shifts include the completion of its acquisition of Nova Pharmaceuticals in December 2024, pivoting development from toxicity reduction to anti-cancer therapeutics and securing concurrent financing to extend cash runway into 2026; followed by the October 2025 sale of its dismutase mimetics portfolio, including avasopasem and rucosopasem, to Biossil Inc. for up to $105 million in milestones to sharpen focus on the NOS inhibitor program in breast cancer.
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