MacroGenics, Inc.
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- MacroGenics, Inc. (NASDAQ: MGNX) is a clinical-stage biopharmaceutical company that discovers, develops, manufactures, and commercializes innovative monoclonal antibody-based therapeutics for cancer treatment; its proprietary platforms include DART molecules, antibody-drug conjugates (ADCs), and Fc-optimized monoclonal antibodies (mAbs). The company, founded in 2000 and headquartered in Rockville, Maryland, focuses on oncology indications such as metastatic castration-resistant prostate cancer (mCRPC), prostate cancer (PROC), colorectal cancer with gynecologic origins (CCGC), and multiple solid tumors, with operations primarily in the United States and partnerships extending globally. Core wholly-owned pipeline candidates comprise lorigerlimab (PD-1 x CTLA-4 DART) in Phase 3 for mCRPC (LORIKEET study) and Phase 2 for PROC/CCGC (LINNET study); MGC026 (B7-H3 ADC), MGC028 (ADAM9 ADC), and MGC030 (undisclosed ADC), all in Phase 1 for solid tumors; partnered programs include MARGENZA (HER2 Fc-optimized mAb, global rights sold to TerSera Therapeutics LLC for $40 million upfront plus up to $35 million milestones), ZYNYZ (PD-1 mAb partnered with Incyte, supplemental BLA anticipated 2H2025 for squamous cell anal carcinoma), TZIELD (CD3 mAb partnered with Sanofi, regulatory decisions expected 2H2025 for type 1 diabetes), MGD024 (CD123 x CD3 DART under Gilead option, up to $1.7 billion potential), and undisclosed DART/TRIDENT bispecifics. Recent developments include a $70 million upfront royalty purchase agreement with Sagard Healthcare Partners for ZYNYZ in Q2 2025, appointment of Eric Risser as President and CEO outlining 2025-2026 priorities for pipeline advancement and capital efficiency, sale of MARGENZA rights to TerSera with an $8 million amendment fee to the prior partner in 4Q2024 and ongoing drug substance manufacturing, IND submission for MGC028 by end-2024 with Phase 1 initiation in 2025, and cash position of $176.5 million as of June 30, 2025, extending into H1 2027.
MacroGenics to Participate in the Stifel 2026 Virtual Targeted Oncology Forum
MacroGenics (MGNX) Reports Q1 Loss, Tops Revenue Estimates
MacroGenics Reports First Quarter 2026 Financial Results and Highlights Business Transformation
MacroGenics to Sell GMP Manufacturing Operations to Bora Pharmaceuticals
MacroGenics to Sell GMP Manufacturing Operations to Bora Pharmaceuticals
Will MacroGenics (MGNX) Report Negative Q1 Earnings? What You Should Know
MacroGenics and Sagard Healthcare Partners Enter into Expanded ZYNYZ® Royalty Purchase Agreement
FDA Removes Partial Clinical Hold on MacroGenics' LINNET Study
MacroGenics (NASDAQ:MGNX) & Medtronic (NYSE:MDT) Critical Review
MacroGenics, Inc. (MGNX) Presents at Barclays 28th Annual Global Healthcare Conference Transcript
MacroGenics (MGNX) Reports Q4 Loss, Tops Revenue Estimates
MacroGenics Reports 2025 Financial Results and Highlights Upcoming Planned Data Disclosures
MacroGenics to Participate in Upcoming Investor Conferences
MacroGenics Announces Pausing of Enrollment of New Study Participants in LINNET Trial
Head to Head Review: MacroGenics (NASDAQ:MGNX) & Sharps Technology (NASDAQ:STSS)
MacroGenics to Participate in the 8th Annual Evercore Healthcare Conference
MacroGenics (MGNX) Q3 Earnings and Revenues Surpass Estimates
MacroGenics Reports Third Quarter 2025 Financial Results and Provides Update on Corporate Progress
MacroGenics (MGNX) Forms 'Hammer Chart Pattern': Time for Bottom Fishing?
MacroGenics to Participate in the Stifel 2025 Healthcare Conference