- CEO
- James Nathanielsz
- Full Time Employees
- 1
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 302, 6 Butler Street Camberwell VIC Australia 3124
- IPO Date
- Nov 12, 2012
- Business
- Propanc Biopharma, Inc. Propanc Biopharma, Inc. (Nasdaq: PPCB) is a clinical-stage biopharmaceutical company that develops novel proenzyme-based therapies to treat recurrent and metastatic solid tumors, primarily targeting pancreatic, ovarian, and colorectal cancers. The company's lead product candidate, PRP, comprises a patented formulation of two proenzymes in a synergistic ratio that induces cancer cell differentiation, inhibits tumor growth and metastasis, suppresses cancer stem cells, blocks angiogenesis, and promotes cell death; its pipeline also includes POP1 in research and Rec-PRP, a fully synthetic recombinant version advancing to preclinical development for enhanced stability and scalability. Headquartered in Camberwell, Australia, and founded in 2007, Propanc operates globally with research collaborations in Spain, including ongoing joint programs with the Universities of Jaén and Granada on POP1 and GMP manufacturing partnerships such as with Q Biologicals. Recent developments include a November 2025 securities purchase agreement with Hexstone Capital LLC for up to $100 million in convertible preferred stock to fund digital asset acquisitions and accelerate R&D, with an initial $1 million tranche received; a closed underwritten public offering of 1,000,000 shares at $4.00 raising $4 million gross proceeds; Nasdaq uplisting with trading commencing August 15, 2025; advancement of PRP toward a Phase 1b first-in-human trial in 30-40 patients with advanced solid tumors at Peter Mac Cancer Center in 2026, supported by GMP scale-up achieving over 95% purity; and negotiation of a 12-month extension for the POP1 program yielding new patent filings on reduced tumorigenicity in gemcitabine-resistant pancreatic cancer.