Protagonist Therapeutics, Inc.
NASDAQ Global MarketCapital Structure
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in mil. unless spec.Company Description
- CEO
- Dinesh V. Patel
- Full Time Employees
- 141
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 7707 Gateway Boulevard Newark CA United States of America 94560
- IPO Date
- Aug 11, 2016
- CIK
- 0001377121
- Website
- protagonist-inc.com
- Similar Companies
- Business
- Protagonist Therapeutics, Inc. (Nasdaq: PTGX) is a clinical-stage biopharmaceutical company that develops novel peptide-based therapeutics targeting unmet needs in hematology, blood disorders, inflammatory, and immunomodulatory diseases. The company leverages a proprietary peptide technology platform, including molecular design tools such as Vectrix™, phage display libraries, oral stability assays, and advanced peptide chemistry, to engineer potent, selective peptides with oral bioavailability for targets like cytokines, receptors, transporters, GPCRs, and ion channels. Its lead product candidates include rusfertide (PTG-300), a hepcidin mimetic in Phase 3 (VERIFY trial) and Phase 2 extensions (REVIVE, THRIVE) for polycythemia vera; and the oral IL-23R antagonist JNJ-2113 (formerly PN-235 or PTG-200), partnered with Janssen (Johnson & Johnson), in Phase 3 for plaque psoriasis and Phase 2b (ANTHEM) for ulcerative colitis; alongside early-stage discovery programs like PN-477 (multi-receptor agonist for obesity), PN-881 (psoriasis), and others for hemochromatosis and hematologic diseases. Founded in 2006 and headquartered in Newark, California, Protagonist operates primarily in the United States with additional presence in Australia. Recent developments include positive Phase 3 data for icotrokinra (JNJ-2113) in plaque psoriasis driving a 32% stock surge in October 2025, plans for a New Drug Application submission for rusfertide in late 2025, advancement of early pipeline candidates with Phase 1 initiations targeted for Q4 2025, and ongoing acquisition discussions with Johnson & Johnson, which already holds a 4% equity stake and commercialization rights to certain assets.
Company News
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Protagonist Therapeutics (NASDAQ:PTGX) CEO Sells $9,289,446.64 in Stock
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Protagonist Therapeutics, Inc. (PTGX) Discusses FDA Approval of Mimrylo for Erythrocytosis in Polycythemia Vera Transcript
Protagonist Wins FDA Approval for MIMRYLO in Rare Blood Cancer Treatment
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Protagonist Therapeutics Announces U.S. FDA Approval of Hepcidin Mimetic Peptide MIMRYLO(TM) (rusfertide) for Polycythemia Vera
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