- CEO
- Raul Silvestre
- Full Time Employees
- 1
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 2629 Townsgate Road Westlake Village CA United States of America 91361
- IPO Date
- Nov 4, 2009
- Business
- Rebus Holdings, Inc. (RBSH) is a clinical-stage biotechnology company focused on the research, development, and commercialization of precision therapeutics targeting the tumor microenvironment to treat cancer; its pipeline centers on adenosine receptor modulators delivered via proprietary nano- or microparticle formulations for intratumoral administration. Core assets include RT-AR001, the lead candidate comprising an A2A adenosine receptor antagonist in nanoparticle form to enhance tumor infiltration and immune response; additional pipeline components encompass selective A2B antagonists, dual A2A/A2B antagonists, and complementary A2A agonists, all aimed at overcoming immunosuppression in solid tumors. The company operates in the immuno-oncology segment of the healthcare industry, targeting oncologists, hospitals, and strategic partners in North America with plans for global expansion; founded in 2003 and headquartered at 2629 Townsgate Road, Suite 215, Westlake Village, California, it employs a lean model with one full-time equivalent and outsources manufacturing to GMP-compliant contract organizations. In October 2021, Rebus Holdings completed a holding company reorganization from Inspyr Therapeutics, Inc., adopting the RBSH ticker and rebranding its website to rebus-corp.com while reacquiring intellectual property rights including US Patent 9,593,118 covering A2A/A2B antagonists following termination of its licensing agreement with Ridgeway Therapeutics; between September 2021 and February 2022, it manufactured GMP-grade RT-AR001 and A2A antagonists sufficient for IND-enabling studies and initial clinical trials, advancing toward an expected IND submission. The company remains pre-revenue with no recent funding rounds, acquisitions, or partnerships disclosed as of late 2025, concentrating efforts on pipeline characterization and clinical candidate selection led by CEO Raul Silvestre.