Silence Therapeutics Plc - American Depository Share
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- Silence Therapeutics plc (Nasdaq: SLN), founded in 1994 and headquartered in Hammersmith, London, with additional offices in Hoboken, New Jersey, USA, and Berlin, Germany, develops proprietary short interfering RNA (siRNA) therapeutics utilizing its mRNAi GOLD™ platform to silence disease-causing genes in the liver for the treatment of rare and cardiovascular diseases. The company advances a wholly owned clinical pipeline including divesiran (SLN124), an siRNA targeting TMPRSS6 for hematological disorders such as beta-thalassemia and myelodysplastic syndromes; zerlasiran (formerly SLN360), an siRNA designed to reduce elevated lipoprotein(a) levels associated with cardiovascular risk, which demonstrated up to 99% reduction in Phase 1 studies lasting 90 days post-dosing; and other candidates like SLN-312, SLN-548 targeting rare diseases. It also licenses siRNA product candidates through partnerships, notably a collaboration with AstraZeneca featuring an ongoing Phase 1 study of SLN312 in an undisclosed indication, alongside prior agreements with Mallinckrodt Pharmaceuticals and Hansoh Pharma. Recent developments encompass pipeline progression with positive clinical data for zerlasiran reported in November 2023, quarterly financial updates through 2025 showing cash reserves exceeding $114 million to support operations into 2028, and strategic focus on high-unmet-need areas in hematology, cardiovascular disease, and rare disorders. Silence Therapeutics operates globally, partnering with pharmaceutical companies to expand its RNAi technology applications across therapeutic areas.
Company News
Silence Therapeutics Investor Alert: Kahn Swick & Foti, LLC Investigates Adequacy of Price and Process in Proposed Sale of Silence Therapeutics plc - SLN
Are BRZE, SLN, OPCH, RXO Obtaining Fair Deals for their Shareholders?
Does Silence Therapeutics (SLN) Have the Potential to Rally 82.84% as Wall Street Analysts Expect?
BRODSKY & SMITH SHAREHOLDER UPDATE: Notifying Investors of the Following Investigations: Silence Therapeutics plc (Nasdaq – SLN), Option Care Health, Inc. (Nasdaq – OPCH), RXO Inc. (NYSE – RXO), Sangoma Technologies Corporation (Nasdaq – SANG)
Silence Therapeutics jumps 59% on Merck takeover
Silence Therapeutics, Disc Medicine, Veradermics And Other Big Stocks Moving Higher On Monday
SLN Stock Alert: Halper Sadeh LLC is Investigating Whether Silence Therapeutics plc is Obtaining a Fair Price for its Shareholders
Germany's Merck to Buy U.K. Biotech Silence Therapeutics for $1.3 Billion
Merck KGaA, Darmstadt, Germany to Acquire Silence Therapeutics, Strengthening Rare Disease Pipeline with Innovative siRNA Asset
Silence Therapeutics Enters into Agreement to be Acquired by Merck KGaA, Darmstadt, Germany
Silence Therapeutics (SLN) Loses 28.8% in 4 Weeks, Here's Why a Trend Reversal May be Around the Corner
Silence Therapeutics (SLN) Upgraded to Buy: Here's Why
Silence Therapeutics (OTCMKTS:SLNCF) Stock Falls 3.7% – Time to Sell?
Absci (NASDAQ:ABSI) vs. Silence Therapeutics (NASDAQ:SLN) Head to Head Contrast
Silence Therapeutics plc (SLN) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript
Silence Therapeutics Announces Closing of Upsized Public Offering and Full Exercise of Underwriters' Option to Purchase Additional ADSs
Wall Street Analysts Predict a 140.06% Upside in Silence Therapeutics (SLN): Here's What You Should Know
Silence Therapeutics Announces Pricing of Upsized $175 Million Underwritten Public Offering
Silence Therapeutics’ Divesiran Hits Phase II Goal, Sets Up Phase III PV Trial
Silence Therapeutics' Divesiran Hits Phase II Goal, Sets Up Phase III PV Trial