Silence Therapeutics plc
NASDAQ Global MarketCapital Structure
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in mil. unless spec.Working Capital
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in mil. unless spec.Growth Rates
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in mil. unless spec.Quarterly Revenue
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in mil. unless spec.Quarterly Earnings Per Share
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in mil. unless spec.Quarterly Dividends Per Share
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in mil. unless spec.- CEO
- Iain Gladstone Ross
- Full Time Employees
- 88
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 72 Hammersmith Road London GL United Kingdom W14 8TH
- IPO Date
- Sep 8, 2020
- CIK
- 0001479615
- Website
- silence-therapeutics.com
- Similar Companies
- Business
- Silence Therapeutics plc (Nasdaq: SLN), founded in 1994 and headquartered in Hammersmith, London, with additional offices in Hoboken, New Jersey, USA, and Berlin, Germany, develops proprietary short interfering RNA (siRNA) therapeutics utilizing its mRNAi GOLD™ platform to silence disease-causing genes in the liver for the treatment of rare and cardiovascular diseases. The company advances a wholly owned clinical pipeline including divesiran (SLN124), an siRNA targeting TMPRSS6 for hematological disorders such as beta-thalassemia and myelodysplastic syndromes; zerlasiran (formerly SLN360), an siRNA designed to reduce elevated lipoprotein(a) levels associated with cardiovascular risk, which demonstrated up to 99% reduction in Phase 1 studies lasting 90 days post-dosing; and other candidates like SLN-312, SLN-548 targeting rare diseases. It also licenses siRNA product candidates through partnerships, notably a collaboration with AstraZeneca featuring an ongoing Phase 1 study of SLN312 in an undisclosed indication, alongside prior agreements with Mallinckrodt Pharmaceuticals and Hansoh Pharma. Recent developments encompass pipeline progression with positive clinical data for zerlasiran reported in November 2023, quarterly financial updates through 2025 showing cash reserves exceeding $114 million to support operations into 2028, and strategic focus on high-unmet-need areas in hematology, cardiovascular disease, and rare disorders. Silence Therapeutics operates globally, partnering with pharmaceutical companies to expand its RNAi technology applications across therapeutic areas.
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