Noile-Immune Biotech Inc. develops chimeric antigen receptor T-cell (CAR-T) therapies targeting solid tumors using its proprietary PRIME technology, exclusively licensed from Yamaguchi University; the company's pipeline includes in-house candidates such as NIB101, NIB102, NIB103, and NIB104, alongside co-development programs like ADAP01 with Adaptimmune Therapeutics plc and AUTL01 with Autolus Therapeutics plc; PRIME enhances CAR-T cell efficacy by expressing IL-7 and CCL19 to activate both engineered T cells and the host immune system, positioning it as a platform applicable to TCR-T cells and other immunotherapies. Founded in 2015 and headquartered in Minato-ku, Tokyo, Japan, with additional facilities in Yamaguchi and Fujisawa, Kanagawa, the company operates primarily in Japan while pursuing global partnerships in the oncology segment focused on cancer immunotherapy drug discovery. Recent developments include the termination of its license agreement with Takeda Pharmaceutical for NIB102 and NIB103 in June 2024, followed by pipeline re-prioritization; completion of clinical trial notification submission for NIB103 Phase I in June 2025; adoption of subsidies from Yamaguchi Prefecture and Ube City in July 2025 for advancing solid tumor CAR-T treatments; and patent registration in Japan in November 2025 for technology related to its developments.