- CEO
- Don Cilla
- Full Time Employees
- 7
- Sector
- Health technology
- Industry
- Pharmaceuticals: major
- Address
- #21-1344 Summer Street Halifax NS Canada B3H 0A8
- IPO Date
- Jun 25, 2019
- Business
- Appili Therapeutics Inc. (TSX: APLI) is a biopharmaceutical company focused on acquiring, developing and commercializing novel anti-infective therapies and medical countermeasures targeting unmet needs in infectious diseases and biodefense; its core pipeline includes LIKMEZ (ATI-1501), an FDA-approved taste-masked oral suspension of metronidazole for anaerobic bacterial, protozoal and parasitic infections commercialized since late 2023 with newly granted patents in 2025; ATI-1801, a topical paromomycin formulation in Phase III for cutaneous leishmaniasis and disfiguring skin infections; ATI-1701, a live-attenuated vaccine candidate in preclinical to clinical stages for tularemia (Francisella tularensis), a serious biothreat; and emerging programs such as a broad-spectrum antiviral host-directed treatment and the VXV-01 fungal vaccine developed with partner Vitalex Biosciences under a NIAID contract valued at up to US$40 million awarded in October 2025. The company, founded in 2015 and headquartered in Halifax, Nova Scotia, Canada, with a U.S. office in Frederick, Maryland, operates primarily in North America while pursuing global biodefense opportunities through collaborations with U.S. government agencies including the Department of Defense, Medical CBRN Defense Consortium, and NIH; it has secured over US$66 million in non-dilutive government funding to date, including recent submissions for up to US$117.5 million in federal proposals in March 2025 and membership in key consortia for advancing countermeasures. Recent developments encompass the formal termination of a proposed going-private arrangement with Aditxt Inc. in May 2025, extension of related timelines, strengthened biodefense positioning via publications on ATI-1701 efficacy and tularemia response in 2025, ongoing regulatory engagements for ATI-1801, and pursuit of Priority Review Vouchers for expedited approvals.