- CEO
- Christopher J. Reinhard
- Full Time Employees
- 3
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 11230 Sorrento Valley Road San Diego CA United States of America 92121
- IPO Date
- May 3, 2000
- Business
- Gene Biotherapeutics, Inc. (CRXM) is a clinical-stage biotechnology company focused on the development and commercialization of angiogenic gene therapy biotherapeutics for the treatment of cardiovascular diseases, particularly myocardial ischemia and refractory angina due to advanced coronary artery disease. The company's lead product candidate, Generx (Ad5FGF-4), is an investigational angiogenic gene therapy in Phase 3 clinical trials under the AFFIRM study; Generx utilizes a replication-deficient adenovirus serotype 5 vector to deliver the human fibroblast growth factor-4 (FGF-4) gene, promoting microvascular growth in ischemic cardiac tissue via a one-time administration during an angiogram-like procedure by interventional cardiologists. It also advances Generx for ischemia-related cardiovascular and cerebral indications, including cardiac microvascular insufficiency, cardiac syndrome X, congestive heart failure, moyamoya disease, and cerebral ischemia; the company pursues advanced tissue engineering applications through its gene therapy platform. Gene Biotherapeutics maintains a manufacturing agreement with Fujifilm Diosynth Biotechnologies for Phase 3 clinical and commercial-scale GMP production of Generx at facilities in College Station, Texas. Founded in 2003 and headquartered at 11230 Sorrento Valley Road, Suite 220, San Diego, California, the company operates primarily in the United States as an 80%-owned operating unit and subsidiary of Nostrum Pharmaceuticals, LLC; it previously operated as Taxus Cardium Pharmaceuticals Group, Inc. until renaming in January 2018. Recent developments include ongoing advancement of the Phase 3 AFFIRM trial for Generx and retention of commercialization rights following the sale of its Excellagen technology platform to Olaregen Therapeutix Inc.