Cyclerion Therapeutics, Inc.
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- Cyclerion Therapeutics, Inc. is a clinical-stage biopharmaceutical entity that has recently undergone a strategic transformation to concentrate on developing innovative therapies for neuropsychiatric conditions. The company’s core focus has shifted to building a new pipeline, with its foundational product candidate being an individualized therapeutic approach for treatment-resistant depression (TRD). This lead program, which is Phase 2-ready, leverages common anesthetic agents alongside a proprietary, technology-driven system to restore functional connectivity by resynchronizing communication between key brain regions. A Phase 2 proof-of-concept trial for this program is projected to commence in 2026, with initial data anticipated in 2027. This strategic pivot follows a licensing agreement with the Massachusetts Institute of Technology (MIT) and a move away from its historical portfolio of soluble guanylate cyclase (sGC) stimulators, such as CY6463, Praliciguat, and Olinciguat, which have been out-licensed or sold to other entities. Founded in 2019, the company maintains its headquarters in Cambridge, Massachusetts.
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Cyclerion Therapeutics, Inc. - Pre Recorded Special Call
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Regina Graul, Ph.D., Promoted to Chief Executive Officer
Cyclerion Appoints Regina Graul, Ph.D., as President
Cyclerion Strengthens Board of Directors with Experienced Company Builder and Cutting-edge Innovator
Tisento Launches with $81 Million From Top-Tier Investor Syndicate and Promising Cyclerion Assets
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