Denali Therapeutics Inc.

Denali Therapeutics Inc.

DNLI
Denali Therapeutics Inc.US flagNASDAQ Global Select
22.28
USD
-0.52
- -
3.54BMarket Cap
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
- -
- -
- -
1.39
0.28
3.08
0.4
0.86
2.41
- -
- -
0.02
Basic EPS, GAAP
-5.58
-13.49
-5.89
-0.39
-2.07
0.65
-2.39
-2.6
-1.06
-2.57
-2.97
-2.83
Free Cash Flow per Basic Share
-6.03
-12.15
-5.31
0.5
-1.77
3.79
-1.81
-2.09
-2.7
-2.21
-2.44
-2.42
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
-0.19
-1.14
5.32
5.78
4.11
9.55
7.87
7.67
7.45
8.53
6.49
5.23
Tangible Book Value per Share
-0.19
-1.14
5.32
5.78
4.11
9.55
7.87
7.67
7.45
8.53
6.49
5.01
Basic Weighted Avg Shares
3
6
15
93
96
109
122
126
137
164
173
180
Sales/Revenue/Turnover
- -
- -
- -
129
27
336
49
108
331
- -
- -
4
Operating Margin (%)
- -
- -
- -
-35.9
-799.1
18.69
-607.78
-314.16
-59.51
- -
- -
-15,058.19
Depreciation Expense
- -
1
3
7
8
9
9
10
17
9
15
16
Net Income, GAAP
-17
-87
-88
-36
-198
71
-291
-326
-145
-423
-513
-511
Effective Tax Rate (%)
- -
- -
- -
- -
- -
1.14
- -
- -
- -
- -
- -
- -
Profit Margin (%)
- -
- -
- -
-28.06
-740.74
21.19
-597.15
-300.56
-43.94
- -
- -
-14,191.2
Working Capital
30
173
395
448
385
1,424
519
1,008
986
762
802
664
LT Debt
- -
- -
- -
- -
69
64
59
53
45
37
27
22
Total Equity
-16
-94
466
547
395
1,151
962
1,042
1,031
1,230
1,014
835
Return on Invested Capital (%)
- -
- -
- -
- -
- -
7.35
- -
- -
- -
- -
- -
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Return on Common Equity (%)
- -
- -
- -
-7.16
-41.97
9.21
-27.51
-32.52
-14.01
-37.4
-45.69
-54.93

Capital Structure

FRC

in mil. unless spec.
Dec'25
Mar'26
Jun'26
ST Debt
10
10
10
LT Borrowings
- -
- -
- -
LT Finance Leases
27
25
22
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
156
159
160
Market Capitalization
2,579
3,046
4,109

Working Capital

FRC

in mil. unless spec.
Dec'25
Mar'26
Jun'26
Total Current Assets
901
1,023
754
Cash, Cash Equivalents & STI
868
988
710
Accounts Receivable, Net
2
- -
4
Inventories
- -
- -
4
Total Current Liabilities
98
110
90
Payables & Accruals
36
76
47
ST Debt
10
10
10
Deferred Revenue
- -
- -
- -

Growth Rates

FRC

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
8.11%
-1.48%
-17.56%
Free Cash Flow
-71.09%
-15.69%
16.09%
Net Income, GAAP
32.89%
-67.88%
21.23%
Sales/Revenue/Turnover
- -
- -
- -
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
4
- -
- -
- -

Quarterly Earnings Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.68
-0.59
-0.63
-0.67
-2.57
2025
-0.78
-0.72
-0.74
-0.73
-2.97
2026
-0.69
-0.68
- -
- -
- -

Quarterly Dividends Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

CEO
Ryan J. Watts
Full Time Employees
503
Sector
Healthcare
Industry
Biotechnology
Address
161 Oyster Point Boulevard South San Francisco CA United States of America 94080
IPO Date
Dec 8, 2017
Business
Denali Therapeutics Inc. (NASDAQ: DNLI) develops therapies for neurodegenerative and lysosomal storage diseases. The company focuses on programs targeting Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and mucopolysaccharidosis type IIIA (MPS IIIA), including DNL343 for ALS and frontotemporal dementia, DNL788 for ALS and Parkinson's, tividenofusp alfa for MPS IIIA, and buntanetap for Alzheimer's; it also advances discovery efforts in other rare diseases. Founded in 2015 and headquartered in South San Francisco, California, Denali operates primarily in the United States with a pipeline built on its proprietary Engineered Antibody Transport (ATLAS) and Enzyme Transport Vehicle (ETV) technologies for crossing the blood-brain barrier. Denali Therapeutics serves the biopharmaceutical industry, targeting patients with neurodegenerative disorders through clinical-stage assets and research collaborations. Its geographic operations center in the U.S., with global partnerships extending research impact. The company maintains subsidiaries like Denali Medtech Inc. for manufacturing support.

Company News

  • BlackRock Inc. Takes Position in Denali Therapeutics Inc. $DNLI

  • DNLI Stock Gains 33.1% in Three Months: Buy, Sell or Hold the Stock?

  • Denali Therapeutics: Bullish On Avlayah And Their Prospects

  • Head to Head Comparison: Denali Therapeutics (NASDAQ:DNLI) versus Humacyte (NASDAQ:HUMA)

  • Denali Therapeutics: AVLAYAH Converts A Platform Story Into A Commercial One

  • Baillie Gifford Trims Denali Therapeutics (DNLI) Stake in June Reduction

  • Denali Therapeutics Inc. $DNLI Shares Acquired by California State Teachers Retirement System

  • DNLI Q2 Loss Narrows, Avlayah Sales Drive Strong Launch Momentum

  • Denali Therapeutics Inc. (DNLI) Q2 2026 Earnings Call Transcript

  • Denali Therapeutics Q2 Earnings Call Highlights

  • Denali Therapeutics Inc. (DNLI) Reports Q2 Loss, Tops Revenue Estimates

  • Denali Therapeutics Reports Second Quarter 2026 Financial Results and Business Highlights

  • Denali Therapeutics to Report Second Quarter 2026 Financial Results and Business Highlights on August 6, 2026

  • Will Recent Setbacks Impact Growth Prospects of DNLI Stock?

  • Denali Therapeutics to Give Opening Plenary Address at Alzheimer's Association International Conference (AAIC) 2026 and Highlight Breakthroughs in Delivering Biologic Therapies Across Blood-Brain Barrier

  • DNLI Stock Surges 59.4% Year to Date: Is There More Room for Growth?

  • Denali to Sell Priority Review Voucher for $195M Cash Boost

  • Denali Therapeutics Enters Agreement to Sell Rare Pediatric Disease Priority Review Voucher for $195 Million

  • Denali Therapeutics Inc. (DNLI) Presents at Jefferies Global Healthcare Conference 2026 Transcript

  • Denali Therapeutics: 'Strong Buy' On AVLAYAH Approval And End Of 2026 FTD-GRN Data