Dyne Therapeutics, Inc.
NASDAQ Global SelectCapital Structure
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in mil. unless spec.Working Capital
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in mil. unless spec.- CEO
- John G. Cox
- Full Time Employees
- 192
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 1560 Trapelo Road Waltham MA United States of America 02451
- IPO Date
- Sep 17, 2020
- CIK
- 0001818794
- Website
- dyne-tx.com
- Similar Companies
- Business
- Dyne Therapeutics, Inc. Dyne Therapeutics, Inc. (NASDAQ: DYN) is a clinical-stage biotechnology company focused on developing nucleic acid therapeutics for genetically driven neuromuscular diseases using its proprietary FORCE platform, which enables targeted delivery of oligonucleotides to muscle and the central nervous system. Founded in 2017 and headquartered in Waltham, Massachusetts, the company advances a broad pipeline including lead clinical candidates z-basivarsen, an antisense oligonucleotide (ASO) conjugated to a transferrin receptor 1-binding Fab for myotonic dystrophy type 1 (DM1) via the Phase 1/2 ACHIEVE trial targeting toxic DMPK RNA reduction; z-rostudirsen, a phosphorodiamidate morpholino oligomer (PMO) conjugated to a TfR1-binding Fab for Duchenne muscular dystrophy (DMD) amenable to exon 51 skipping via the Phase 1/2 DELIVER trial aiming to restore dystrophin production; preclinical programs such as DYNE-302, an siRNA conjugate for facioscapulohumeral muscular dystrophy (FSHD) suppressing DUX4 expression; additional DMD candidates targeting exons 53, 45, and 44; and efforts in Pompe disease, with global operations pursuing regulatory designations across the U.S., EU, and Japan. Core offerings emphasize muscle-targeted therapies addressing root causes like spliceopathy in DM1 affecting approximately 40,000 U.S. patients, dystrophin loss in DMD impacting 12,000 U.S. individuals, and DUX4 toxicity in FSHD; z-basivarsen and z-rostudirsen have secured FDA Breakthrough Therapy, Fast Track, Orphan Drug, and Rare Pediatric designations, alongside EMA and Japanese approvals. Recent developments include FDA Breakthrough Therapy Designation for DYNE-101 (z-basivarsen) in DM1 in June 2025 and for DYNE-251 (z-rostudirsen) in DMD in August 2025; full enrollment of registrational expansion cohorts in ACHIEVE and DELIVER trials with data expected mid-2026 and late 2025 to support potential U.S. accelerated approval submissions in 2026; closure of a $230 million public stock offering in July 2025 extending cash runway into Q3 2027; plans for confirmatory Phase 3 DM1 trial initiation in Q1 2026; leadership team enhancements in early 2025 ahead of anticipated 2027 commercial launches; and ongoing preclinical expansion in DMD exons and Pompe disease.
Dyne Therapeutics Announces Completion of Enrollment in Registrational Expansion Cohort of ACHIEVE Trial of Z-Basivarsen for Myotonic Dystrophy Type 1 (DM1)
Dyne Therapeutics Stock Gains 4.5% After BLA Filing for DMD Therapy
Dyne Therapeutics Announces Submission of Biologics License Application (BLA) to U.S. FDA for Z-Rostudirsen in Exon 51 Duchenne Muscular Dystrophy (DMD)
Dyne Therapeutics: 'Strong Buy' Due To Upcoming Z-Rostudirsen BLA Submission
Dyne Stock Gains 10% on Initiation of Late-Stage Study in DMD Patients
Dyne Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Dyne Therapeutics Announces Initiation of Phase 3 FORZETTO Trial of Z-Rostudirsen in Duchenne Muscular Dystrophy (DMD) Ahead of Planned BLA Submission for U.S. Accelerated Approval
Dyne Therapeutics Is Up 40%, but One Biotech Fund Just Disclosed Selling $14 Million Worth of Shares
Dyne Therapeutics to Participate in Upcoming Investor Conferences
Dyne Therapeutics (DYN) Upgraded to Buy: Here's What You Should Know
Dyne Therapeutics Reports First Quarter 2026 Financial Results and Recent Business Highlights
Dyne Therapeutics Reports First Quarter 2026 Financial Results and Recent Business Highlights
Dyne Therapeutics Announces Upcoming Presentation Highlighting Robust CNS Activity in Nonhuman Primates with its FORCE™ Platform at 2026 ASGCT Annual Meeting
Jason Rhodes Sells 272,049 Shares of Dyne Therapeutics (NASDAQ:DYN) Stock
Dyne Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Darwin Wealth Management LLC Sells 58,250 Shares of Dyne Therapeutics, Inc. $DYN
Aberdeen Group plc Purchases 551,412 Shares of Dyne Therapeutics, Inc. $DYN
Head-To-Head Analysis: MediWound (NASDAQ:MDWD) & Dyne Therapeutics (NASDAQ:DYN)
Dyne Therapeutics Announces Participation at 2026 Academy of Managed Care Pharmacy (AMCP) Conference to Begin Shaping Access in US for Potential Neuromuscular Medicines
Dyne Therapeutics (NASDAQ:DYN) Stock Price Up 4.4% – Here’s Why