Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

IONS
Ionis Pharmaceuticals, Inc.US flagNASDAQ Global Select
53.39
USD
+0.44
- -
8.82BMarket Cap
Ionis Pharmaceuticals, Inc.
IONS
(NASDAQ Global Select)

Recent

price

53.39

P/E

ratio

- -

div

yld

- -

ROIC.AI

2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
TTM
FRC
1.09
0.99
1.01
1.33
1.82
2.37
3.08
4.15
4.53
8.02
5.21
5.75
4.14
5.51
4.7
5.9
6.55
Revenue per Share
-0.62
-0.85
-0.65
-0.55
-0.33
-0.74
-0.5
- -
2.07
1.99
-3.17
-0.2
-1.9
-2.56
-3.03
-2.38
-2.02
Basic EPS, GAAP
-0.82
-1.26
-0.03
0.53
-0.04
0.08
-1.02
1.1
4.42
2.21
-0.04
0.09
-2.07
-2.35
-3.68
-2.04
-6.05
Free Cash Flow per Basic Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Dividend per Share
-7.63
-8.44
-9.02
-8.76
-8.55
-9.14
-9.77
-10.01
-7.31
-5.05
-8.08
-8.23
-10.07
-12.56
-15
-16.44
-16.86
Book Value per Share
2.31
1.47
1.57
3.24
2.04
1.52
0.65
2.77
8.79
11.85
5.11
5.27
4.03
2.7
3.92
3.06
3.04
Tangible Book Value per Share
99
100
101
111
118
120
121
124
132
140
140
141
142
143
150
160
162
Basic Weighted Avg Shares
108
99
102
147
214
284
373
514
600
1,123
729
810
587
788
705
944
1,058
Sales/Revenue/Turnover
-44.58
-71.76
-67.54
-35.08
-22.29
-26.7
-5.41
6.04
-10.23
32.59
-20.56
-1.82
-69.84
-44.91
-67.38
-40.45
-33.29
Operating Margin (%)
9
12
11
10
9
10
9
8
13
16
17
20
22
22
22
23
25
Depreciation Expense
-61
-85
-65
-61
-39
-88
-60
- -
274
278
-444
-29
-270
-366
-454
-381
-327
Net Income, GAAP
- -
- -
- -
- -
- -
- -
- -
- -
- -
15.2
- -
- -
- -
- -
- -
- -
- -
Effective Tax Rate (%)
-56.47
-85.58
-64.16
-41.17
-18.2
-31.12
-16.2
0.07
45.65
24.78
-60.92
-3.53
-45.92
-46.5
-64.37
-40.41
-30.9
Profit Margin (%)
377
284
349
638
721
688
664
925
1,928
2,448
1,532
2,104
1,891
2,194
2,311
2,209
2,220
Working Capital
149
211
215
222
447
462
573
593
628
770
600
1,248
1,362
1,400
1,407
1,610
1,608
LT Debt
245
171
183
378
258
201
100
365
1,187
1,685
743
772
573
387
588
489
491
Total Equity
- -
- -
- -
- -
- -
- -
- -
- -
- -
14.37
- -
- -
- -
- -
- -
- -
- -
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
609.27
- -
- -
- -
- -
- -
- -
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Return on Common Equity (%)

Capital Structure

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
ST Debt
631
455
432
LT Borrowings
596
1,347
1,349
LT Finance Leases
263
262
259
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
161
163
166
Market Capitalization
10,402
12,658
12,127

Working Capital

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
Total Current Assets
2,519
2,991
2,937
Cash, Cash Equivalents & STI
2,240
2,677
1,919
Accounts Receivable, Net
- -
- -
- -
Inventories
10
10
6
Total Current Liabilities
903
782
717
Payables & Accruals
114
137
155
ST Debt
631
455
432
Deferred Revenue
77
74
69

Growth Rates

FRC

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
40.83%
-3.83%
-16.87%
Free Cash Flow
-414.4%
-539.18%
-40.93%
Net Income, GAAP
7,941.9%
158.67%
-15.97%
Sales/Revenue/Turnover
17.92%
8.21%
33.83%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
119
225
134
227
705
2025
132
452
157
203
944
2026
246
- -
- -
- -
- -

Quarterly Earnings Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.98
-0.45
-0.94
-0.66
-3.03
2025
-0.92
0.78
-0.8
-1.42
-2.38
2026
-0.56
- -
- -
- -
- -

Quarterly Dividends Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -
Business
Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) develops and commercializes RNA-targeted therapeutics for patients with rare diseases and other unmet medical needs. The company utilizes its proprietary antisense technology platform to design drugs that modulate RNA and protein expression; its marketed products include Spinraza (nusinersen) for spinal muscular atrophy, Tegsedi (inotersen) and Waylivra (volanesorsen) for rare cardiovascular and metabolic diseases; and its pipeline encompasses candidates such as pelacarsen for cardiovascular disease, olezarsen for familial chylomicronemia syndrome and familial partial lipodystrophy, and donidalorsen for hereditary angioedema. Ionis operates primarily in the biotechnology sector, targeting pharmaceutical companies through licensing agreements and direct commercialization in select markets, with global operations spanning the United States, Europe, and other regions. Founded in 1989 and headquartered in Carlsbad, California, the company maintains subsidiaries including Akcea Therapeutics, which focuses on commercializing certain antisense medicines prior to its integration into Ionis. In recent developments, Ionis completed the acquisition of certain assets from Novartis in 2024, including rights to pelacarsen; announced positive Phase 3 topline results for olezarsen in severe hypertriglyceridemia in mid-2025; and entered a strategic collaboration with Moderna in late 2024 to develop antisense-based therapies for cardiovascular indications. Additionally, the company reported its Q3 2025 financial results in November 2025, highlighting pipeline advancements and royalty revenues exceeding $200 million from Spinraza, alongside preparations for multiple regulatory filings in 2026.

Company News

APIChatGPT
  • INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Ionis Pharmaceuticals, Inc. - IONS

  • Amova Asset Management Americas Inc. Has $6.13 Million Stock Position in Ionis Pharmaceuticals, Inc. $IONS

  • Ionis Pharmaceuticals: The Heartbreak Is Priced In

  • INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Ionis Pharmaceuticals, Inc. - IONS

  • Ionis Pharmaceuticals, Inc. (IONS) Faces Investor Scrutiny After Surprise Trial Failure Drives Stock Down 23% – HBSS

  • Biogen Shares Decline After Detailed Diranersen Alzheimer's Study Data

  • Ionis to hold second quarter 2026 financial results webcast

  • INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Ionis Pharmaceuticals, Inc. - IONS

  • INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Ionis Pharmaceuticals, Inc. - IONS

  • Ionis Pharmaceuticals, Inc. (IONS) Faces Investor Scrutiny After Surprise Trial Failure Drives Stock Down 23% – HBSS

  • Ionis Begins Dosing in Phase I/II Dravet Syndrome Study

  • Levi & Korsinsky Notifies Investors of a Pending Investigation Into Securities Claims Involving Ionis Pharmaceuticals (IONS)

  • Ionis Partner Biogen Presents Phase 2 CELIA Data at AAIC Demonstrating Meaningful Clinical Outcomes and Robust Tau Reduction with Diranersen in Early Alzheimer's Disease

  • Ionis Partner Biogen Presents Phase 2 CELIA Data at AAIC Demonstrating Meaningful Clinical Outcomes and Robust Tau Reduction with Diranersen in Early Alzheimer's Disease

  • The Phase 3 Failure That Sent Biotech Winners and Losers in Opposite Directions

  • IONS Investor Alert: Levi & Korsinsky Notifies Investors of an Investigation Into Ionis Pharmaceuticals (IONS)

  • Ionis doses first participant in Phase 1-2 ASCEND study of ION337 in Dravet syndrome

  • Ionis Pharmaceuticals Drops Another 9% as Bad News Piles Up

  • Ionis, AstraZeneca Stumble in ATTR-CM Trial as Rivals Stand to Gain

  • IONS SHAREHOLDER INVESTIGATION: SueWallSt Notifies Investors of Potential Securities Claims Involving Ionis Pharmaceuticals