1. United States of America Stocks

  2. •

    Healthcare

  3. •

    Biotechnology
Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

IONS
Ionis Pharmaceuticals, Inc.US flagNASDAQ Global Select
72.97
USD
-2.41
- -
12.06BMarket Cap

Income Statement (USD)

APIChat
2011 Y
2012 Y
2013 Y
2014 Y
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
Sales/Revenue/Turnover
99
102
147
214
284
373
514
600
1,123
729
810
587
788
705
944
+ Sales & Services Revenue
99
102
147
214
284
373
514
600
1,123
729
810
587
788
705
944
- Cost of Revenue
- -
158
184
242
322
- -
- -
2
4
12
11
14
9
11
16
+ Cost of Goods & Services
- -
158
184
242
322
- -
- -
2
4
12
11
14
9
11
16
Gross Profit
99
-56
-37
-28
-39
373
514
598
1,118
717
800
573
779
694
928
+ Other Operating Income
- -
-158
-184
-242
-322
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- Operating Expenses
170
171
199
262
359
393
483
659
752
867
814
983
1,132
1,169
1,310
+ Selling, General & Admin
13
13
15
20
37
49
108
245
287
332
171
150
233
268
394
+ Research & Development
157
158
184
242
322
344
375
415
466
535
643
833
900
902
916
+ Other Operating Expense
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Operating Income (Loss)
-71
-69
-52
-48
-76
-20
31
-61
366
-150
-15
-410
-354
-475
-382
- Non-Operating (Income) Loss
14
6
15
7
12
37
48
15
27
-15
14
-152
-20
-15
-2
+ Interest Expense, Net
14
21
19
22
37
39
45
45
12
6
4
8
81
84
84
+ Interest Expense
17
21
19
22
37
39
45
45
12
6
4
8
81
84
84
- Interest Income
2
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other Non-Op (Income) Loss
-1
-15
-4
-16
-25
-1
3
-30
15
-22
10
-160
-101
-99
-86
Pretax Income
-85
-75
-67
-54
-88
-57
-17
-76
339
-135
-29
-258
-334
-460
-380
- Income Tax Expense (Benefit)
- -
-9
-6
-15
- -
3
-6
-291
52
345
-1
12
32
-6
2
- (Income) Loss from Affiliates
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Income (Loss) from Cont Ops
-85
-65
-61
-39
-88
-60
-11
215
287
-480
-29
-270
-366
-454
-381
- Net Extraordinary Losses (Gains)
- -
- -
- -
- -
- -
- -
-22
-118
18
-71
- -
- -
- -
- -
- -
+ Discontinued Operations
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Extraord. & Accounting Changes
- -
- -
- -
- -
- -
- -
-22
-118
18
-71
- -
- -
- -
- -
- -
Income (Loss) Incl. MI
-85
-65
-61
-39
-88
-60
11
332
269
-409
-29
-270
-366
-454
-381
- Minority Interest
- -
- -
- -
- -
- -
- -
11
59
-9
35
- -
- -
- -
- -
- -
Net Income, GAAP
-85
-65
-61
-39
-88
-60
- -
274
278
-444
-29
-270
-366
-454
-381
- Preferred Dividends
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- Other Adjustments
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Net Income Avail to Common, GAAP
-85
-65
-61
-39
-88
-60
- -
274
278
-444
-29
-270
-366
-454
-381
EBIT
-71
-69
-52
-48
-76
-20
31
-61
366
-150
-15
-410
-354
-475
-382
EBITDA
-59
-58
-42
-38
-66
-11
39
-49
382
-133
5
-388
-331
-453
-359
EBITDA Margin (%)
-59.86
-57
-28.44
-17.9
-23.1
-2.98
7.66
-8.15
34.02
-18.21
0.59
-66.07
-42.05
-64.26
-38.04
EBITA
-71
-69
-52
-48
-76
-20
31
-61
366
-150
-15
-410
-354
-475
-382
Gross Margin (%)
100
-55.28
-24.95
-12.88
-13.6
100
100
99.7
99.61
98.36
98.66
97.6
98.84
98.41
98.31
Operating Margin (%)
-71.76
-67.54
-35.08
-22.29
-26.7
-5.41
6.04
-10.23
32.59
-20.56
-1.82
-69.84
-44.91
-67.38
-40.45
Profit Margin (%)
-85.58
-64.16
-41.17
-18.2
-31.12
-16.2
0.07
45.65
24.78
-60.92
-3.53
-45.92
-46.5
-64.37
-40.41
Sales per Employee
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Depreciation Expense
12
11
10
9
10
9
8
13
16
17
20
22
22
22
23
Basic Weighted Avg Shares
100
101
111
118
120
121
124
132
140
140
141
142
143
150
160
Basic EPS, GAAP
-0.85
-0.65
-0.55
-0.33
-0.74
-0.5
- -
2.07
1.99
-3.17
-0.2
-1.9
-2.56
-3.03
-2.38
Basic EPS from Cont Ops
-0.85
-0.65
-0.55
-0.33
-0.74
-0.5
-0.09
1.62
2.05
-3.43
-0.2
-1.9
-2.56
-3.03
-2.38
Diluted Weighted Avg Shares
100
101
111
118
120
121
126
134
143
140
141
142
143
150
160
Diluted EPS, GAAP
-0.85
-0.65
-0.55
-0.33
-0.74
-0.5
- -
2.04
1.95
-3.17
-0.2
-1.9
-2.56
-3.03
-2.38
Diluted EPS from Cont Ops
-0.85
-0.65
-0.55
-0.33
-0.74
-0.5
-0.09
1.6
2.01
-3.43
-0.2
-1.9
-2.56
-3.03
-2.38

Balance Sheet (USD)

APIChat
2011 Y
2012 Y
2013 Y
2014 Y
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
Total Current Assets
360
423
736
837
837
798
1,169
2,208
2,721
2,131
2,345
2,203
2,642
2,620
2,991
+ Cash, Cash Equivalents & STI
344
408
709
811
804
665
1,023
2,084
2,500
1,892
2,115
1,987
2,331
2,298
2,677
+ Cash & Cash Equivalents
65
124
160
143
129
85
130
279
683
398
869
276
399
242
372
+ ST Investments
278
284
549
668
675
581
893
1,805
1,816
1,495
1,246
1,710
1,932
2,056
2,305
+ Accounts & Notes Receiv
7
1
11
4
11
108
63
13
63
76
62
26
98
92
66
+ Accounts Receivable, Net
7
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Notes Receivable, Net
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Loans Receivable, Net
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other Receivable, Net
- -
1
11
4
11
108
63
13
63
76
62
26
98
92
66
+ Inventories
4
6
8
6
7
7
10
9
18
22
25
22
7
13
10
+ Raw Materials
- -
- -
- -
- -
- -
- -
- -
- -
16
17
19
20
2
6
1
+ Work In Process
- -
- -
- -
- -
- -
- -
- -
- -
2
2
6
2
5
7
8
+ Finished Goods
- -
- -
- -
- -
- -
- -
- -
- -
- -
3
- -
- -
- -
- -
1
+ Inventory Adjustments
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other Inventory
4
6
8
6
7
7
10
9
- -
- -
- -
- -
- -
- -
- -
+ Other ST Assets
5
9
8
16
15
17
73
102
140
140
143
168
205
218
237
+ Misc ST Assets
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Prepaid Expenses
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ ST Derivative & Hedging Assets
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ ST Assets Held-for-Sale
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ ST Deferred Tax Assets
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Total Noncurrent Assets
125
122
112
119
111
115
154
460
513
259
267
331
348
383
533
+ Property, Plant & Equip, Net
97
91
86
89
90
93
122
132
154
181
196
256
243
256
362
+ Property, Plant & Equip
144
146
147
155
163
173
210
194
228
268
299
344
340
362
471
- Accumulated Depreciation
47
54
60
66
73
80
88
61
74
87
103
88
97
106
109
+ LT Investments & Receivables
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ LT Investments
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ LT Receivables
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other LT Assets
28
31
25
30
21
22
32
328
359
78
71
75
105
127
172
+ Total Intangible Assets
25
25
20
17
19
20
22
24
26
28
29
- -
- -
- -
- -
+ Goodwill
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other Intangible Assets
25
25
20
17
19
20
22
24
26
28
29
- -
- -
- -
- -
+ LT Deferred Tax Assets
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ LT Derivative & Hedging Assets
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Misc LT Assets
3
6
5
13
1
1
10
304
333
50
42
75
105
127
172
Total Assets
485
546
847
956
948
912
1,323
2,668
3,233
2,390
2,612
2,534
2,990
3,004
3,524
+ Payables & Accruals
27
26
33
48
56
57
92
77
115
109
100
164
176
151
137
+ Accounts Payable
8
10
11
18
28
21
25
29
16
17
12
18
26
43
28
+ Accrued Taxes
- -
- -
- -
- -
- -
- -
- -
1
33
1
- -
6
2
- -
3
+ Interest & Dividends Payable
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other Payables & Accruals
19
15
22
30
28
36
67
48
67
90
89
140
148
108
106
+ ST Debt
3
5
4
3
9
1
2
14
2
309
4
8
53
9
455
+ ST Borrowings
3
5
4
3
9
1
2
14
2
309
4
8
53
9
455
+ ST Finance Leases
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other ST Liabilities
46
44
60
64
83
75
150
190
156
181
137
140
219
149
190
+ Deferred Revenue
37
36
48
52
67
51
125
160
118
108
98
91
151
79
74
+ Derivatives & Hedging
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Deferred Tax Liabilities
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Misc ST Liabilities
9
8
12
12
16
24
25
29
37
73
39
49
68
70
116
Total Current Liabilities
76
74
98
115
149
134
244
280
273
599
241
312
448
309
782
+ LT Debt
211
215
222
447
462
573
593
628
770
600
1,248
1,362
1,400
1,407
1,610
+ LT Borrowings
141
144
150
376
389
501
593
628
770
600
1,228
1,183
1,230
1,245
1,347
+ LT Finance Leases
70
71
71
72
72
72
- -
- -
- -
- -
19
179
171
162
262
+ Other LT Liabilities
26
74
149
135
137
106
121
572
506
447
352
288
755
699
643
+ Accrued Liabilities
17
67
143
128
134
91
108
567
490
424
352
288
241
157
92
+ Pension Liabilities
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Deferred Revenue
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Deferred Tax Liabilities
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Derivatives & Hedging
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Misc LT Liabilities
9
7
7
8
2
15
13
5
16
23
- -
- -
514
542
551
Total Noncurrent Liabilities
237
289
371
583
598
679
714
1,200
1,276
1,048
1,599
1,649
2,155
2,106
2,253
Total Liabilities
313
363
469
698
747
813
957
1,481
1,549
1,646
1,840
1,961
2,603
2,415
3,035
+ Preferred Equity and Hybrid Capital
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Share Capital & APIC
1,014
1,077
1,325
1,225
1,309
1,311
1,554
2,047
2,204
1,896
1,964
2,060
2,215
2,869
3,146
+ Common Stock
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Additional Paid in Capital
1,014
1,077
1,325
1,225
1,309
1,311
1,554
2,047
2,204
1,896
1,964
2,060
2,215
2,869
3,145
- Treasury Stock
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Retained Earnings
-841
-907
-968
-1,007
-1,095
-1,181
-1,241
-967
-708
-1,131
-1,160
-1,430
-1,796
-2,250
-2,631
+ Other Equity
-1
12
21
40
-14
-30
-32
-32
-25
-21
-33
-57
-33
-31
-25
Equity Before Minority Interest
171
183
378
258
201
100
281
1,048
1,471
743
772
573
387
588
489
+ Minority/Non Controlling Interest
- -
- -
- -
- -
- -
- -
84
139
213
- -
- -
- -
- -
- -
- -
Total Equity
171
183
378
258
201
100
365
1,187
1,685
743
772
573
387
588
489
Total Liabilities & Equity
485
546
847
956
948
912
1,323
2,668
3,233
2,390
2,612
2,534
2,990
3,004
3,524
Shares Outstanding
100
101
116
118
120
122
125
138
140
140
141
142
144
158
163
Number of Employees
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Capital Leases - Total
70
71
71
72
72
72
- -
- -
- -
- -
19
179
171
162
262
Net Debt
79
24
-5
235
270
417
465
363
89
511
362
914
883
1,013
1,430
Net Debt to Equity
46.29
13.34
-1.38
91.31
134.27
418.83
127.26
30.58
5.27
68.78
46.96
159.5
228.45
172.12
292.35
Tangible Common Equity Ratio
31.8
30.27
43.32
25.63
19.54
8.88
26.39
44
51.72
30.29
28.76
22.61
12.93
19.59
13.88
Current Ratio
4.73
5.7
7.52
7.25
5.62
5.96
4.8
7.88
9.97
3.56
9.75
7.07
5.9
8.47
3.83
Cash Conversion Cycle
- -
3.11
-6.82
-11.23
-18.72
- -
- -
-21,405.51
530.27
227.34
399.11
125.7
2,058.19
-448.42
-705.57

Cash Flow Statement (USD)

APIChat
2011 Y
2012 Y
2013 Y
2014 Y
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
+ Net Income
-85
-65
-61
-39
-88
-60
-11
215
287
-480
-29
-270
-366
-454
-381
+ Depreciation & Amortization
12
11
10
9
10
9
8
13
16
17
20
22
22
22
23
+ Non-Cash Items
28
6
28
31
79
117
140
-124
211
572
154
-34
114
140
141
+ Stock-Based Compensation
10
9
11
31
59
72
86
131
147
230
121
100
106
130
134
+ Deferred Income Taxes
- -
-9
-6
-13
- -
- -
- -
-291
1
342
- -
- -
- -
- -
- -
+ Asset Impairment Charge
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other Non-Cash Adj
19
7
23
12
19
45
54
35
64
- -
33
-135
8
10
7
+ Chg in Non-Cash Work Cap
-67
50
86
5
20
-178
37
499
-169
-74
-114
8
-77
-209
-51
+ (Inc) Dec in Accts Receiv
-6
6
-11
7
-7
-97
45
48
-48
-13
14
36
-72
6
26
+ (Inc) Dec in Inventories
-2
-2
-2
2
-1
-1
-2
1
-5
-1
-3
5
-2
-5
-14
+ (Inc) Dec in Prepaid Assets
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Inc (Dec) in Accts Payable
10
-3
11
9
11
3
32
-14
8
58
-41
58
21
-25
37
+ Inc (Dec) in Other
-70
49
87
-13
18
-84
-37
465
-124
-117
-84
-92
-24
-185
-100
+ Net Cash From Disc Ops
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Cash from Operating Activities
-112
2
63
6
21
-112
174
603
346
36
31
-274
-308
-501
-269
+ Change in Fixed & Intang
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Disp in Fixed & Intang
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Disp of Fixed Prod Assets
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Disp of Intangible Assets
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Acq of Fixed & Intang
-14
-5
-5
-11
-12
-12
-38
-18
-36
-41
-18
-20
-28
-50
-57
+ Acq of Fixed Prod Assets
-10
-1
-2
-8
-8
-7
-35
-14
-31
-35
-12
-16
-24
-45
-51
+ Acq of Intangible Assets
-4
-4
-4
-4
-4
-4
-3
-4
-5
-6
-6
-4
-4
-5
-6
+ Cash (Repurchase) of Equity
- -
- -
173
23
25
13
255
476
85
-39
12
6
49
523
193
+ Increase in Capital Stock
- -
- -
173
23
25
13
255
476
120
52
12
6
49
523
193
+ Decrease in Capital Stock
- -
- -
- -
- -
- -
- -
- -
- -
-34
-91
- -
- -
- -
- -
- -
+ Net Change in LT Investment
122
23
-250
-95
-74
64
-323
-912
-5
316
213
-497
-186
-84
-221
+ Dec in LT Investment
493
245
175
297
420
365
557
883
1,952
1,886
1,344
989
1,585
1,769
1,698
+ Inc in LT Investment
-371
-222
-426
-392
-493
-301
-880
-1,795
-1,957
-1,570
-1,131
-1,486
-1,771
-1,853
-1,919
+ Net Cash From Acq & Div
- -
-3
- -
23
26
4
3
- -
- -
- -
- -
- -
- -
- -
- -
+ Cash from Divestitures
- -
- -
- -
23
26
4
3
- -
- -
- -
- -
- -
- -
- -
- -
+ Cash for Acq of Subs
- -
-3
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Cash for JVs
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Other Investing Activities
- -
3
- -
- -
- -
- -
- -
- -
- -
- -
- -
254
- -
- -
- -
+ Net Cash From Disc Ops
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Cash from Investing Activities
108
18
-256
-83
-60
57
-358
-930
-41
274
195
-263
-214
-134
-278
+ Dividends Paid
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
+ Net Cash From Debt
-6
21
-11
35
-1
-3
56
- -
97
- -
314
-51
87
-45
502
+ Cash From Debt
- -
195
- -
487
8
4
60
- -
110
- -
632
- -
575
- -
770
+ Repayments of Debt
-6
-174
-11
-452
-9
-7
-4
- -
-12
- -
-319
-51
-488
-45
-268
+ Other Financing Activities
5
19
65
1
- -
1
-82
- -
-82
-558
-79
-11
508
- -
-19
+ Net Cash From Disc Ops
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Cash from Financing Activities
-1
39
228
60
25
11
229
476
100
-597
246
-55
644
478
676
Effect of Foreign Exchange Rates
- -
- -
- -
- -
- -
- -
- -
- -
- -
1
- -
- -
- -
- -
1
Net Changes in Cash
-5
59
35
-17
-14
-44
45
149
404
-286
472
-592
122
-157
129
EBITDA
-59
-58
-42
-38
-66
-11
39
-49
382
-133
5
-388
-331
-453
-359
EBITDA Margin (%)
-59.86
-57
-28.44
-17.9
-23.1
-2.98
7.66
-8.15
34.02
-18.21
0.59
-66.07
-42.05
-64.26
-38.04
Free Cash Flow
-126
-3
58
-5
9
-124
136
585
309
-5
13
-294
-336
-551
-326
Net Cash Paid for Acquisitions
- -
3
- -
-23
-26
-4
-3
- -
- -
- -
- -
- -
- -
- -
- -
Free Cash Flow to Firm
- -
- -
- -
- -
- -
- -
- -
- -
320
- -
- -
- -
- -
- -
- -
Free Cash Flow to Equity
-128
21
51
34
13
-122
196
589
412
1
332
-341
-244
-591
182
Free Cash Flow per Basic Share
-1.26
-0.03
0.53
-0.04
0.08
-1.02
1.1
4.42
2.21
-0.04
0.09
-2.07
-2.35
-3.68
-2.04
Price/Free Cash Flow
-7.33
149.02
63.94
417.86
225.54
-57.51
29.92
11.68
22.62
102.88
88.1
-21.09
-25.88
-11.64
-59.85
Cash Flow to Net Income
1.32
-0.03
-1.05
-0.16
-0.24
1.86
503.32
2.2
1.24
-0.08
-1.08
1.02
0.84
1.1
0.7
Capital Expenditures
-14
-5
-5
-11
-12
-12
-38
-18
-36
-41
-18
-20
-28
-50
-57