Ionis Pharmaceuticals, Inc. Financial Ratios — IONS Stock

Profitability (USD)

	2011 Y	2012 Y	2013 Y	2014 Y	2015 Y	2016 Y	2017 Y	2018 Y	2019 Y	2020 Y	2021 Y	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2011	12/31/2012	12/31/2013	12/31/2014	12/31/2015	12/31/2016	12/31/2017	12/31/2018	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Return on Common Equity (%)	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -
Return on Assets (%)	-16.38	-12.71	-8.71	-4.32	-9.27	-6.49	0.03	13.72	9.43	-15.8	-1.14	-10.48	-13.26	-15.15	-11.69
Return on Capital (%)	- -	- -	- -	- -	- -	- -	- -	- -	609.27	- -	- -	- -	- -	- -	- -
Return on Invested Capital (%)	- -	- -	- -	- -	- -	- -	- -	- -	14.37	- -	- -	- -	- -	- -	- -
Gross Margin (%)	100	-55.28	-24.95	-12.88	-13.6	100	100	99.7	99.61	98.36	98.66	97.6	98.84	98.41	98.31
EBITDA Margin (%)	-59.86	-57	-28.44	-17.9	-23.1	-2.98	7.66	-8.15	34.02	-18.21	0.59	-66.07	-42.05	-64.26	-38.04
Operating Margin (%)	-71.76	-67.54	-35.08	-22.29	-26.7	-5.41	6.04	-10.23	32.59	-20.56	-1.82	-69.84	-44.91	-67.38	-40.45
Incremental Operating Margin (%)	- -	- -	- -	- -	- -	- -	36.21	- -	81.7	- -	- -	- -	- -	- -	- -
Pretax Margin (%)	-85.57	-73.09	-45.19	-25.4	-30.99	-15.42	-3.26	-12.7	30.18	-18.45	-3.6	-43.92	-42.4	-65.25	-40.22
Profit Margin (%)	-85.58	-64.16	-41.17	-18.2	-31.12	-16.2	0.07	45.65	24.78	-60.92	-3.53	-45.92	-46.5	-64.37	-40.41
Net Income to Common Margin (%)	-85.58	-64.16	-41.17	-18.2	-31.12	-16.2	0.07	45.65	24.78	-60.92	-3.53	-45.92	-46.5	-64.37	-40.41
Effective Tax Rate (%)	- -	- -	- -	- -	- -	- -	- -	- -	15.2	- -	- -	- -	- -	- -	- -
Dvd Payout Ratio (%)	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -
Sustainable Growth Rate (%)	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -

Credit (USD)

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	2011 Y	2012 Y	2013 Y	2014 Y	2015 Y	2016 Y	2017 Y	2018 Y	2019 Y	2020 Y	2021 Y	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2011	12/31/2012	12/31/2013	12/31/2014	12/31/2015	12/31/2016	12/31/2017	12/31/2018	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Total Debt	215	219	226	450	471	574	595	642	772	909	1,251	1,369	1,454	1,417	2,065
ST Debt	3	5	4	3	9	1	2	14	2	309	4	8	53	9	455
LT Debt	211	215	222	447	462	573	593	628	770	600	1,248	1,362	1,400	1,407	1,610
Total Debt/EBITDA	-3.62	-3.77	-5.4	-11.74	-7.18	-51.59	15.09	-13.14	2.02	-6.84	259.5	-3.53	-4.39	-3.13	-5.75
Net Debt/EBITDA	-1.34	-0.42	0.12	-6.14	-4.11	-37.48	11.8	-7.43	0.23	-3.85	75.18	-2.35	-2.67	-2.23	-3.98
Total Debt/EBIT	-3.02	-3.18	-4.37	-9.43	-6.21	-28.47	19.15	-10.46	2.11	-6.06	-84.88	-3.34	-4.11	-2.98	-5.41
Net Debt/EBIT	-1.12	-0.35	0.1	-4.93	-3.56	-20.69	14.97	-5.91	0.24	-3.41	-24.59	-2.23	-2.5	-2.13	-3.75
EBITDA to Interest Expense	-3.55	-2.75	-2.16	-1.73	-1.78	-0.29	0.88	-1.09	30.7	-21.08	1.1	-47.78	-4.07	-5.37	-4.26
EBITDA-CapEx/Interest Expense	-4.37	-2.99	-2.44	-2.23	-2.1	-0.58	0.03	-1.48	27.78	-27.59	-2.97	-50.26	-4.41	-5.97	-4.94
EBIT to Interest Expense	-4.25	-3.26	-2.67	-2.15	-2.06	-0.52	0.69	-1.37	29.41	-23.8	-3.35	-50.5	-4.34	-5.63	-4.53
Interest Expense	17	21	19	22	37	39	45	45	12	6	4	8	81	84	84
Common Equity/Total Assets	-173.52	-166.19	-114.2	-105.3	-115.49	-129.46	-93.81	-36.25	-21.88	-47.33	-44.41	-56.41	-60.06	-74.9	-74.66
Long-Term Debt/Equity (%)	123.27	117.39	58.57	173.49	229.89	575.37	162.31	52.9	45.71	80.74	161.65	237.68	362.15	239.19	329.15
Long-Term Debt/Capital (%)	-33.72	-31.21	-29.89	-80.38	-73.96	-94.34	-105.47	-337.18	276.92	-270.04	1,366.58	-2,258.59	-409.19	-168.93	-284.16
Long-Term Debt/Total Assets (%)	43.58	39.32	26.16	46.79	48.7	62.78	44.82	23.54	23.81	25.11	47.77	53.74	46.83	46.85	45.68
Total Debt/Equity (%)	125.25	120.05	59.73	174.61	234.38	576.56	162.75	54.06	45.83	122.29	162.11	239	375.9	240.77	422.11
Total Debt/Capital (%)	-34.26	-31.92	-30.48	-80.9	-75.4	-94.53	-105.76	-344.56	277.65	-408.99	1,370.44	-2,271.09	-424.73	-170.04	-364.42
Total Debt/Total Assets (%)	44.28	40.21	26.68	47.09	49.65	62.91	44.94	24.06	23.88	38.03	47.9	54.04	48.61	47.16	58.59
Net Debt to Equity	46.29	13.34	-1.38	91.31	134.27	418.83	127.26	30.58	5.27	68.78	46.96	159.5	228.45	172.12	292.35
Net Debt/Capital (%)	-11.47	-3	0.58	-33.66	-35.81	-60.27	-67.2	-78.05	-21.89	-82.48	-46.59	-271.35	-119.14	-94.19	-152.31
EBITDA	-59	-58	-42	-38	-66	-11	39	-49	382	-133	5	-388	-331	-453	-359
EBITDA-CapEx	-73	-63	-47	-49	-77	-23	2	-66	346	-174	-13	-408	-359	-503	-416
Operating Income (Loss)	-71	-69	-52	-48	-76	-20	31	-61	366	-150	-15	-410	-354	-475	-382

Liquidity (USD)

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	2011 Y	2012 Y	2013 Y	2014 Y	2015 Y	2016 Y	2017 Y	2018 Y	2019 Y	2020 Y	2021 Y	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2011	12/31/2012	12/31/2013	12/31/2014	12/31/2015	12/31/2016	12/31/2017	12/31/2018	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Cash Ratio	4.52	5.49	7.25	7.03	5.4	4.97	4.2	7.44	9.16	3.16	8.79	6.38	5.2	7.43	3.43
Current Ratio	4.73	5.7	7.52	7.25	5.62	5.96	4.8	7.88	9.97	3.56	9.75	7.07	5.9	8.47	3.83
Quick Ratio	4.61	5.5	7.36	7.06	5.48	5.78	4.46	7.48	9.39	3.29	9.05	6.46	5.42	7.73	3.51
CFO/Avg Current Liab	-1.23	0.02	0.74	0.06	0.16	-0.79	0.92	2.3	1.25	0.08	0.07	-0.99	-0.81	-1.32	-0.49
Common Equity/Total Assets	-173.52	-166.19	-114.2	-105.3	-115.49	-129.46	-93.81	-36.25	-21.88	-47.33	-44.41	-56.41	-60.06	-74.9	-74.66
Long-Term Debt/Equity (%)	123.27	117.39	58.57	173.49	229.89	575.37	162.31	52.9	45.71	80.74	161.65	237.68	362.15	239.19	329.15
Long-Term Debt/Capital (%)	-33.72	-31.21	-29.89	-80.38	-73.96	-94.34	-105.47	-337.18	276.92	-270.04	1,366.58	-2,258.59	-409.19	-168.93	-284.16
Long-Term Debt/Total Assets (%)	43.58	39.32	26.16	46.79	48.7	62.78	44.82	23.54	23.81	25.11	47.77	53.74	46.83	46.85	45.68
Total Debt/Equity (%)	125.25	120.05	59.73	174.61	234.38	576.56	162.75	54.06	45.83	122.29	162.11	239	375.9	240.77	422.11
Total Debt/Capital (%)	-34.26	-31.92	-30.48	-80.9	-75.4	-94.53	-105.76	-344.56	277.65	-408.99	1,370.44	-2,271.09	-424.73	-170.04	-364.42
Total Debt/Total Assets (%)	44.28	40.21	26.68	47.09	49.65	62.91	44.94	24.06	23.88	38.03	47.9	54.04	48.61	47.16	58.59
CFO/Total Liabilities	-35.71	0.52	13.54	0.9	2.83	-13.79	18.19	40.72	22.32	2.18	1.67	-13.99	-11.81	-20.74	-8.85
CFO/CapEx	-8.07	0.36	11.84	0.57	1.8	-9.72	4.6	34.16	9.53	0.87	1.72	-13.65	-10.99	-9.95	-4.71
Altman's Z-Score	-0.74	-0.14	4.89	5.73	5.23	3.65	3.9	3.41	4.61	3.09	2.04	1.44	1.58	0.89	2.12

Working Capital (USD)

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	2011 Y	2012 Y	2013 Y	2014 Y	2015 Y	2016 Y	2017 Y	2018 Y	2019 Y	2020 Y	2021 Y	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2011	12/31/2012	12/31/2013	12/31/2014	12/31/2015	12/31/2016	12/31/2017	12/31/2018	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Accounts Receivable Turnover	24.28	29.49	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -
Days Sales Outstanding	15.03	12.38	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -
Inventory Turnover	- -	30.89	26	33.76	48.87	- -	- -	0.2	0.33	0.6	0.46	0.6	0.62	1.12	1.41
Days Inventory Outstanding	- -	11.82	14.04	10.81	7.47	- -	- -	1,861.5	1,114.07	613.25	787.28	605.56	588.96	324.69	258.8
Accounts Payable Turnover	0.22	17.31	17.5	16.56	13.94	0.02	0.11	0.02	0.63	0.95	0.94	0.76	-0.25	0.47	0.38
Accounts Payable Turnover Days	1,634.56	21.09	20.85	22.05	26.19	15,303.71	3,367.87	23,267.01	583.8	385.9	388.17	479.86	-1,469.23	773.11	964.37
Cash Conversion Cycle	- -	3.11	-6.82	-11.23	-18.72	- -	- -	-21,405.51	530.27	227.34	399.11	125.7	2,058.19	-448.42	-705.57
Inventory to Cash Days	- -	0.56	-14.04	-10.81	-7.47	- -	- -	-1,861.5	-1,114.07	-613.25	-787.28	-605.56	-588.96	-324.69	-258.8
Inventories	4	6	8	6	7	7	10	9	18	22	25	22	7	13	10
Raw Materials	- -	- -	- -	- -	- -	- -	- -	- -	16	17	19	20	2	6	1
Work In Process	- -	- -	- -	- -	- -	- -	- -	- -	2	2	6	2	5	7	8
Finished Goods	- -	- -	- -	- -	- -	- -	- -	- -	- -	3	- -	- -	- -	- -	1
Other Inventory	4	6	8	6	7	7	10	9	- -	- -	- -	- -	- -	- -	- -

Enterprise Value (USD)

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	2011 Y	2012 Y	2013 Y	2014 Y	2015 Y	2016 Y	2017 Y	2018 Y	2019 Y	2020 Y	2021 Y	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2011	12/31/2012	12/31/2013	12/31/2014	12/31/2015	12/31/2016	12/31/2017	12/31/2018	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Market Capitalization	719	1,050	4,402	7,266	7,414	5,784	6,238	7,153	8,457	7,916	4,291	5,363	7,234	5,244	12,658
- Cash & Cash Equivalents	65	124	160	143	129	85	130	279	683	398	869	276	399	242	372
+ Preferred Equity and Hybrid Capital	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -
+ Minority/Non Controlling Interest	- -	- -	- -	- -	- -	- -	84	139	213	- -	- -	- -	- -	- -	- -
+ Total Debt	215	219	226	450	471	574	595	642	772	909	1,251	1,369	1,454	1,417	2,065
Enterprise Value	590	861	3,920	6,906	7,081	5,693	5,894	5,850	6,943	6,932	3,427	4,746	6,357	4,363	12,045
Total Capital	-627	-687	-741	-556	-624	-607	-562	-186	278	-222	91	-60	-342	-833	-567
Total Debt/Capital (%)	-34.26	-31.92	-30.48	-80.9	-75.4	-94.53	-105.76	-344.56	277.65	-408.99	1,370.44	-2,271.09	-424.73	-170.04	-364.42
Total Debt / EV	0.36	0.25	0.06	0.07	0.07	0.1	0.1	0.11	0.11	0.13	0.37	0.29	0.23	0.32	0.17
EV/Sales	5.95	8.44	26.61	32.25	24.96	15.27	11.46	9.76	6.19	9.51	4.23	8.08	8.07	6.19	12.76
EV/EBITDA	- -	- -	- -	- -	- -	- -	149.61	- -	18.18	- -	710.79	- -	- -	- -	- -
EV/EBIT	- -	- -	- -	- -	- -	- -	189.84	- -	18.98	- -	- -	- -	- -	- -	- -
EV/Cash Flow to Firm	- -	42.13	48.31	311.02	122.06	- -	29.04	12.28	19.49	118.79	97.58	- -	- -	- -	- -
EV/Free Cash Flow to Firm	- -	33.63	45.32	207.33	101.5	- -	24.48	11.84	17.69	69.74	64.63	- -	- -	- -	- -
Diluted Market Cap	719	1,050	4,402	7,266	7,414	5,784	6,343	7,247	8,639	7,916	4,291	5,363	7,234	5,244	12,658
Diluted Enterprise Value	868	1,145	4,468	7,573	7,756	6,274	6,892	7,749	8,941	8,427	4,672	6,456	8,289	6,418	14,350
EV per Share	5.92	8.56	35.47	58.68	59.15	47.08	47.53	44.21	49.59	49.52	24.3	33.42	44.45	29.09	75.28
TTM Sales	99	102	147	214	284	373	514	600	1,123	729	810	587	788	705	944
TTM EBITDA	-59	-58	-42	-38	-66	-11	39	-49	382	-133	5	-388	-331	-453	-359
TTM Operating Income	-71	-69	-52	-48	-76	-20	31	-61	366	-150	-15	-410	-354	-475	-382
TTM Cash Flow to Firm	-95	20	81	22	58	-71	203	476	356	58	35	-266	-218	-418	-184
TTM Free Cash Flow to Firm	-81	26	86	33	70	-60	241	494	392	99	53	-246	-190	-367	-127

Multiples (USD)

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	2011 Y	2012 Y	2013 Y	2014 Y	2015 Y	2016 Y	2017 Y	2018 Y	2019 Y	2020 Y	2021 Y	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2011	12/31/2012	12/31/2013	12/31/2014	12/31/2015	12/31/2016	12/31/2017	12/31/2018	12/31/2019	12/31/2020	12/31/2021	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Price/Free Cash Flow	-7.33	149.02	63.94	417.86	225.54	-57.51	29.92	11.68	22.62	102.88	88.1	-21.09	-25.88	-11.64	-59.85
EV/EBIT	- -	- -	- -	- -	- -	- -	189.84	- -	18.98	- -	- -	- -	- -	- -	- -
Enterprise Value	590	861	3,920	6,906	7,081	5,693	5,894	5,850	6,943	6,932	3,427	4,746	6,357	4,363	12,045
Low Price	6.25	7.02	10.36	22.25	37.38	19.59	37.26	39.07	52.45	39.32	25.04	28.25	32.69	33.33	23.95
EV/Sales	5.95	8.44	26.61	32.25	24.96	15.27	11.46	9.76	6.19	9.51	4.23	8.08	8.07	6.19	12.76
EV/EBITDA	- -	- -	- -	- -	- -	- -	149.61	- -	18.18	- -	710.79	- -	- -	- -	- -
Price/Earnings	- -	- -	- -	- -	- -	- -	18,028.92	26.13	30.41	- -	- -	- -	- -	- -	- -
Price/Earnings Average	-9.72	-15.77	-46.62	-124.2	-80.24	-71.8	17,811.4	23.32	32.7	-17.07	-201.44	-20.37	-16.13	-14.24	-20.03
Price/Earnings High	-12.28	-23.98	-77.79	-202.63	-105.51	-125.5	23,480.6	28.91	43.58	-20.28	-317.38	-25.7	-20.41	-17.99	-35.08
Price/Earnings Low	-7.34	-10.78	-18.88	-67.17	-50.69	-39.23	13,355.02	18.89	26.4	-12.39	-123.46	-14.87	-12.76	-11.01	-10.05
Price/Book Value	-0.85	-1.16	-4.55	-7.22	-6.77	-4.9	-5.03	-7.4	-11.96	-7	-3.7	-3.75	-4.03	-2.33	-4.81
Price/Book Value Average	-0.98	-1.14	-2.92	-4.81	-6.47	-3.67	-4.97	-6.6	-12.86	-6.7	-4.97	-3.84	-3.29	-2.87	-2.9
Price/Book Value High	-1.24	-1.73	-4.88	-7.85	-8.51	-6.42	-6.55	-8.18	-17.14	-7.96	-7.83	-4.85	-4.16	-3.63	-5.08
Price/Book Value Low	-0.74	-0.78	-1.18	-2.6	-4.09	-2.01	-3.72	-5.35	-10.38	-4.87	-3.04	-2.81	-2.6	-2.22	-1.46
Price/Tangible Book Value	4.92	6.67	12.29	30.2	40.86	73.03	18.17	6.15	5.1	11.07	5.78	9.36	18.71	8.91	25.88
Price/Tangible Book Value Average	5.64	6.55	7.89	20.12	39.03	54.76	17.95	5.49	5.48	10.6	7.76	9.59	15.28	10.99	15.62
Price/Tangible Book Value High	7.13	9.97	13.17	32.83	51.32	95.71	23.67	6.8	7.31	12.59	12.22	12.1	19.33	13.88	27.35
Price/Tangible Book Value Low	4.26	4.48	3.2	10.88	24.66	29.92	13.46	4.44	4.43	7.7	4.75	7	12.09	8.5	7.83
Price/Sales	7.25	10.29	29.89	33.93	26.13	15.52	12.13	11.93	7.53	10.85	5.29	9.13	9.18	7.44	13.41
Price/Sales Average	8.32	10.12	19.2	22.61	24.97	11.63	11.99	10.64	8.1	10.4	7.11	9.36	7.5	9.17	8.1
Price/Sales High	10.51	15.38	32.03	36.89	32.83	20.33	15.8	13.2	10.8	12.35	11.2	11.8	9.49	11.58	14.18
Price/Sales Low	6.29	6.92	7.77	12.23	15.77	6.36	8.99	8.62	6.54	7.55	4.36	6.83	5.93	7.09	4.06
Price/Cash Flow	-6.42	559.71	69.34	1,156.12	350.97	-51.6	35.82	11.86	24.47	220.54	139.31	-19.55	-23.53	-10.47	-47.13
Price/Cash Flow Average	-7.36	550.41	44.53	770.35	335.31	-38.69	35.39	10.59	26.32	211.29	187.04	-20.03	-19.21	-12.91	-28.45
Price/Cash Flow High	-9.3	836.88	74.3	1,256.87	440.91	-67.62	46.65	13.13	35.07	250.96	294.69	-25.27	-24.31	-16.3	-49.81
Price/Cash Flow Low	-5.56	376.36	18.03	416.65	211.84	-21.14	26.53	8.57	21.25	153.37	114.63	-14.62	-15.2	-9.98	-14.27
Price/Free Cash Flow Average	-8.4	146.55	41.06	278.43	215.48	-43.12	29.56	10.42	24.33	98.57	118.29	-21.61	-21.13	-14.35	-36.12
Price/Free Cash Flow High	-10.62	222.82	68.51	454.28	283.34	-75.37	38.96	12.92	32.42	117.07	186.37	-27.26	-26.74	-18.12	-63.25
Price/Free Cash Flow Low	-6.35	100.2	16.63	150.59	136.13	-23.56	22.16	8.44	19.64	71.55	72.5	-15.78	-16.72	-11.1	-18.12
EV/Sales Average	9.82	11.05	19.64	24.04	26.17	12.95	13.05	11.48	8.37	11.1	7.58	11.22	8.84	10.83	9.89
EV/Sales High	12.02	16.31	32.48	38.32	34.04	21.65	16.87	14.03	11.07	13.05	11.67	13.66	10.83	13.25	15.97
EV/Sales Low	7.79	7.85	8.22	13.66	16.98	7.67	10.05	9.46	6.81	8.25	4.83	8.69	7.27	8.76	5.85
EV/EBITDA Average	-16.41	-19.38	-69.08	-134.34	-113.32	-433.75	170.37	-140.96	24.61	-60.96	1,274.11	-16.98	-21.02	-16.86	-25.99
EV/EBITDA High	-20.07	-28.62	-114.21	-214.12	-147.37	-725.21	220.16	-172.31	32.53	-71.68	1,961.84	-20.68	-25.75	-20.61	-41.97
EV/EBITDA Low	-13.02	-13.77	-28.91	-76.34	-73.51	-256.92	131.23	-116.12	20.02	-45.3	811.55	-13.15	-17.3	-13.63	-15.39
EV/EBIT Average	-13.69	-16.36	-56	-107.87	-98.01	-239.4	216.18	-112.18	25.69	-53.98	-416.75	-16.06	-19.68	-16.08	-24.45
EV/EBIT High	-16.75	-24.16	-92.58	-171.94	-127.45	-400.27	279.36	-137.13	33.96	-63.48	-641.7	-19.56	-24.11	-19.66	-39.48
EV/EBIT Low	-10.86	-11.62	-23.44	-61.3	-63.58	-141.8	166.52	-92.42	20.9	-40.12	-265.45	-12.44	-16.2	-12.99	-14.47
Last Price	7.21	10.44	39.84	61.74	61.93	47.83	50.3	54.06	60.41	56.54	30.43	37.77	50.59	34.96	79.11
High Price	10.45	15.61	42.69	67.12	77.8	62.68	65.51	59.81	86.58	64.34	64.37	48.82	52.27	54.44	83.61
Enterprise Value Average	973	1,128	2,893	5,149	7,425	4,826	6,712	6,885	9,398	8,095	6,142	6,588	6,962	7,640	9,332
Enterprise Value High	1,191	1,665	4,783	8,207	9,656	8,069	8,673	8,416	12,424	9,519	9,458	8,025	8,529	9,340	15,070
Enterprise Value Low	772	801	1,211	2,926	4,817	2,859	5,170	5,672	7,645	6,016	3,912	5,104	5,729	6,174	5,524

Shares Outstanding	100	101	116	118	120	122	125	138	140	140	141	142	144	158	163
Diluted Weighted Avg Shares	100	101	111	118	120	121	126	134	143	140	141	142	143	150	160
Basic Weighted Avg Shares	100	101	111	118	120	121	124	132	140	140	141	142	143	150	160
Revenue per Share	0.99	1.01	1.33	1.82	2.37	3.08	4.15	4.53	8.02	5.21	5.75	4.14	5.51	4.7	5.9
EBITDA per Share	-0.6	-0.58	-0.38	-0.33	-0.55	-0.09	0.32	-0.37	2.73	-0.95	0.03	-2.73	-2.32	-3.02	-2.24
Operating Income per Share	-0.71	-0.69	-0.47	-0.41	-0.63	-0.17	0.25	-0.46	2.61	-1.07	-0.1	-2.89	-2.47	-3.17	-2.39
Basic EPS, GAAP	-0.85	-0.65	-0.55	-0.33	-0.74	-0.5	- -	2.07	1.99	-3.17	-0.2	-1.9	-2.56	-3.03	-2.38
Basic EPS from Cont Ops	-0.85	-0.65	-0.55	-0.33	-0.74	-0.5	-0.09	1.62	2.05	-3.43	-0.2	-1.9	-2.56	-3.03	-2.38
Diluted EPS, GAAP	-0.85	-0.65	-0.55	-0.33	-0.74	-0.5	- -	2.04	1.95	-3.17	-0.2	-1.9	-2.56	-3.03	-2.38
Diluted EPS from Cont Ops	-0.85	-0.65	-0.55	-0.33	-0.74	-0.5	-0.09	1.6	2.01	-3.43	-0.2	-1.9	-2.56	-3.03	-2.38
Dividend per Share	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -	- -
Cash Flow per Share	-1.12	0.02	0.57	0.05	0.18	-0.93	1.4	4.56	2.47	0.26	0.22	-1.93	-2.15	-3.34	-1.68
Free Cash Flow per Basic Share	-1.26	-0.03	0.53	-0.04	0.08	-1.02	1.1	4.42	2.21	-0.04	0.09	-2.07	-2.35	-3.68	-2.04
Cash & Equivalents per Share	3.45	4.06	6.41	6.89	6.72	5.5	8.25	15.75	17.85	13.52	15	13.99	16.3	15.32	16.73
Book Value per Share	-8.44	-9.02	-8.76	-8.55	-9.14	-9.77	-10.01	-7.31	-5.05	-8.08	-8.23	-10.07	-12.56	-15	-16.44
Tangible Book Value per Share	1.47	1.57	3.24	2.04	1.52	0.65	2.77	8.79	11.85	5.11	5.27	4.03	2.7	3.92	3.06

Ionis Pharmaceuticals, Inc.

Profitability (USD)

Credit (USD)

Liquidity (USD)

Working Capital (USD)

Enterprise Value (USD)

Multiples (USD)

Per Share Data Items (USD)