Prelude Therapeutics Incorporated
NASDAQ Global SelectCapital Structure
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in mil. unless spec.Working Capital
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in mil. unless spec.Growth Rates
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in mil. unless spec.Quarterly Revenue
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in mil. unless spec.Quarterly Earnings Per Share
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in mil. unless spec.Quarterly Dividends Per Share
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in mil. unless spec.- CEO
- Krishna Vaddi
- Full Time Employees
- 79
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 175 Innovation Boulevard Wilmington DE United States of America 19803
- IPO Date
- Sep 25, 2020
- CIK
- 0001678660
- Website
- preludetx.com
- Similar Companies
- Business
- Prelude Therapeutics Incorporated (Nasdaq: PRLD) is a clinical-stage precision oncology company that discovers and develops small molecule therapies targeting key driver mechanisms in genomically defined cancers with high unmet needs. The company's diversified pipeline comprises highly selective targeted protein degraders and inhibitors, including KAT6A degraders for ER-positive breast cancer and other solid tumors; mutant selective JAK2V617F JH2 inhibitors for myeloproliferative neoplasms; selective CDK9 inhibitors such as PRT2527 for solid tumors and hematological malignancies; next-generation CDK4/6 inhibitors such as PRT3645 for advanced solid tumors; and degrader antibody conjugates (DACs) incorporating novel payloads for next-generation oncology applications. Founded in 2016 and headquartered in Wilmington, Delaware, Prelude operates primarily in the United States with a focus on underserved patient populations across solid tumors and hematologic cancers. In November 2025, Prelude announced a strategic business update that included pausing development of its SMARCA2 degrader program, including PRT3789, following disappointing Phase 1 data that highlighted challenges in treating aggressive SMARCA4-deficient cancers; the company concurrently entered an exclusive option agreement with Incyte Therapeutics for its preclinical mutant selective JAK2V617F JH2 inhibitor program, receiving $35 million in upfront cash and $25 million in equity investment, with potential milestone payments up to $775 million if the option is exercised. Prelude is advancing its KAT6A degrader toward clinical trials in 2026 for ER+ breast cancer and reported third quarter 2025 financial results affirming a strengthened cash position to support prioritized programs. The company also appointed Katina Dorton, J.D., MBA, to its board of directors in October 2025, adding expertise in healthcare finance and life sciences governance.
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