Prothena Corporation plc
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- Prothena Corporation plc, a clinical-stage biotechnology company focused on the discovery and development of novel investigational therapies targeting protein dysregulation in neurodegenerative and rare peripheral amyloid diseases, advances a pipeline including PRX012, an anti-amyloid beta monoclonal antibody in Phase 1 for early Alzheimer's disease with data expected in 2025; prasinezumab, a humanized monoclonal antibody targeting alpha-synuclein in Phase 2b for Parkinson's disease and other synucleinopathies; coramitug for transthyretin amyloidosis (ATTR-CM); BMS-986446 and PRX019 targeting tau and TDP-43 respectively in collaboration with Bristol Myers Squibb; and PRX123, a preclinical dual amyloid beta-tau vaccine. The company, founded in 2012 through a spin-off from Elan Corporation plc and headquartered in Dublin, Ireland, with research operations in South San Francisco, California, serves patient populations affected by devastating conditions such as Alzheimer's disease, Parkinson's disease, ALS, and ATTR amyloidosis primarily in the United States and globally through partnerships. Recent developments include the discontinuation of the birtamimab program for AL amyloidosis following the Phase 3 AFFIRM-AL trial failure, a shift emphasizing PRX012 as the lead wholly-owned asset with higher-dose subcutaneous formulations advancing toward topline results in August 2025; progression of partnered programs with Roche on prasinezumab potentially entering Phase 3 by year-end 2025, Novo Nordisk's Phase 2 data for coramitug in the second half of 2025, and Bristol Myers Squibb's ongoing tau and TDP-43 efforts; and initiation of a Phase 1 trial for PRX019 in Q3 2025 alongside a poster presentation on its TDP-43 program at Neuroscience 2025.
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