Pyxis Oncology, Inc.

Pyxis Oncology, Inc.

PYXS
Pyxis Oncology, Inc.US flagNASDAQ Global Select
1.71
USD
-0.08
- -
108.34MMarket Cap
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
- -
- -
- -
- -
- -
0.28
- -
0.22
Basic EPS, GAAP
-0.13
-0.58
-8.95
-3.65
-1.85
-1.32
- -
-0.93
Free Cash Flow per Basic Share
-0.1
-0.52
-4.22
-2.9
-1.94
-0.99
- -
-0.65
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
-0.13
-0.71
-10.8
-6.43
-7.17
-6.22
- -
- -
Tangible Book Value per Share
-0.13
-0.71
30.77
4.87
2.54
2.02
- -
- -
Basic Weighted Avg Shares
22
22
8
33
40
58
- -
63
Sales/Revenue/Turnover
- -
- -
- -
- -
- -
16
14
14
Operating Margin (%)
- -
- -
- -
- -
- -
-424.23
-609.18
-443.83
Depreciation Expense
- -
- -
1
1
2
3
5
4
Net Income, GAAP
-3
-13
-76
-121
-74
-77
-80
-58
Effective Tax Rate (%)
- -
- -
- -
- -
- -
- -
- -
- -
Profit Margin (%)
- -
- -
- -
- -
- -
-478.95
-574.55
-421.87
Working Capital
19
4
260
155
99
115
51
- -
LT Debt
- -
- -
- -
19
20
19
17
- -
Total Equity
-3
-16
261
161
126
121
53
- -
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
Return on Common Equity (%)
- -
- -
- -
- -
- -
- -
- -
- -

Capital Structure

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
ST Debt
2
2
- -
LT Borrowings
- -
- -
- -
LT Finance Leases
17
17
- -
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
62
63
- -
Market Capitalization
137
71
91

Working Capital

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
Total Current Assets
83
72
- -
Cash, Cash Equivalents & STI
76
67
- -
Accounts Receivable, Net
- -
- -
- -
Inventories
- -
- -
- -
Total Current Liabilities
19
21
- -
Payables & Accruals
18
16
- -
ST Debt
2
2
- -
Deferred Revenue
- -
- -
- -

Growth Rates

FRC

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
- -
-378.06%
-55.77%
Free Cash Flow
- -
68.47%
9.67%
Net Income, GAAP
- -
104.01%
2.96%
Sales/Revenue/Turnover
- -
- -
-14.17%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
16
- -
- -
- -
16
2025
- -
3
- -
11
14
2026
- -
- -
- -
- -
- -

Quarterly Earnings Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.06
-0.29
-0.35
- -
-1.32
2025
-0.35
-0.3
-0.35
- -
- -
2026
- -
- -
- -
- -
- -

Quarterly Dividends Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

APIChat
CEO
Thomas Civik
Full Time Employees
44
Sector
Healthcare
Industry
Biotechnology
Address
35 Cambridgepark Drive Boston MA United States of America 02140
IPO Date
Oct 8, 2021
Business
Pyxis Oncology, Inc. (PYXS) is a clinical-stage biotechnology company that develops antibody-drug conjugates and immunotherapies targeting difficult-to-treat solid tumors. The company offers a pipeline of product candidates including PYX-201, a lead investigational ADC comprising human immunoglobulin G1 targeting extradomain-B fibronectin in Phase 1 trials for relapsed or refractory solid tumors such as head and neck squamous cell carcinoma; PYX-106, a Siglec-15-targeting monoclonal antibody in Phase 1 for advanced solid tumors; PYX-107, a CD40 agonist monoclonal antibody in Phase 2 for soft tissue sarcomas, esophageal and gastroesophageal junction cancers, and pancreatic ductal adenocarcinoma; PYX-203, an ADC licensed from Pfizer Inc.; and additional candidates leveraging its proprietary Flexible Antibody Conjugation Technology platform combined with the APXiMAB antibody-discovery platform. Pyxis Oncology, founded in 2018 and headquartered in Boston, Massachusetts, operates primarily in the United States with a focus on oncology therapeutics for patients with advanced cancers. Recent strategic developments include the 2023 acquisition of Apexigen, adding a validated Phase 2-ready antibody platform and expanding ADC capabilities while maintaining cash runway into 2026; in-licensing deals with Pfizer for ADC candidates like PYX-201 and PYX-203, and with Biosion USA for PYX-106; positive November 2024 Phase 1 data for PYX-201 showing 50% objective response rate in head and neck squamous cell carcinoma; and December 2024 portfolio prioritization to focus resources on PYX-201 monotherapy and combination trials, including with Keytruda in front-line settings, while deprioritizing PYX-106.

Company News

APIChat
  • Pyxis Oncology Reports First Quarter 2026 Financial Results and Advances MICVO Toward Key 2026 Clinical Milestones

  • Pyxis Oncology to Participate in Upcoming Investor Conferences

  • Pyxis Oncology Appoints Nelson Azoulay as Chief Business Officer

  • Pyxis Oncology to Present New Preclinical Data Showing Synergistic Anti-Tumor Activity in a HNSCC model with maMICVO in Combination with Anti-PD-1 at AACR 2026

  • Pyxis Oncology Provides Business Update and Reports Fourth Quarter and Full Year 2025 Financial Results

  • Pyxis Oncology (PYXS) Projected to Post Quarterly Earnings on Tuesday

  • Pyxis Oncology, Inc. (NASDAQ:PYXS) Given Average Rating of “Moderate Buy” by Brokerages

  • Pyxis Oncology Announces Interim CEO Appointment and Leadership Transition to Support Strategic Focus and Program Continuity

  • Pyxis Oncology, Inc. (NASDAQ:PYXS) Short Interest Update

  • Pyxis Oncology, Inc. (NASDAQ:PYXS) Given Consensus Recommendation of “Moderate Buy” by Brokerages

  • Analysts Sound Alarm On Pyxis Oncology's Tiny Trial

  • Pyxis Oncology, Inc. (PYXS) Discusses Preliminary Phase 1 Data for MICVO in Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma Transcript

  • Pyxis Oncology Announces Positive Preliminary Phase 1 Data for Micvotabart Pelidotin (MICVO) in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

  • Pyxis Oncology to Participate in Upcoming Investor Conferences

  • Pyxis Oncology Provides Business Update and Reports Third Quarter 2025 Financial Results

  • Pyxis Oncology (PYXS) Upgraded to Strong Buy: Here's What You Should Know

  • 5 Small Drug Stocks to Buy as the Industry Shows Some Recovery

  • Pyxis Oncology to Present Translational Data and Key Biology Findings Elucidating the Mechanism of Action of MICVO at Upcoming Medical Meetings

  • Pyxis Oncology Appoints Alex Kane as Senior Vice President, Investor Relations & Capital Markets

  • Pyxis Oncology Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)