Pyxis Oncology, Inc.

Pyxis Oncology, Inc.

PYXS
Pyxis Oncology, Inc.US flagNASDAQ Global Select
1.85
USD
+0.09
- -
116.89MMarket Cap
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
- -
- -
- -
- -
- -
0.28
0.22
0.17
Basic EPS, GAAP
-0.13
-0.58
-8.95
-3.65
-1.85
-1.32
-1.28
-1.4
Free Cash Flow per Basic Share
-0.1
-0.52
-4.22
-2.9
-1.94
-0.99
-1.02
-1.07
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
-0.09
-0.49
8.11
4.6
2.81
2.01
0.85
0.18
Tangible Book Value per Share
-0.09
-0.49
8.11
4.6
2.27
1.97
0.85
0.18
Basic Weighted Avg Shares
22
22
8
33
40
58
62
63
Sales/Revenue/Turnover
- -
- -
- -
- -
- -
16
14
11
Operating Margin (%)
- -
- -
- -
- -
- -
-424.23
-609.18
-834.44
Depreciation Expense
- -
- -
1
1
2
3
5
4
Net Income, GAAP
-3
-13
-76
-121
-74
-77
-80
-89
Effective Tax Rate (%)
- -
- -
- -
- -
- -
- -
- -
- -
Profit Margin (%)
- -
- -
- -
- -
- -
-478.95
-574.55
-803.83
Working Capital
19
4
260
155
99
115
51
9
LT Debt
- -
- -
- -
19
20
19
17
16
Total Equity
-3
-16
261
161
126
121
53
11
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
Return on Common Equity (%)
- -
- -
- -
-57.19
-51.51
-62.75
-91.43
-179.1

Capital Structure

FRC

•

in mil. unless spec.
Dec'25
Mar'26
Jun'26
ST Debt
2
2
2
LT Borrowings
- -
- -
- -
LT Finance Leases
17
16
16
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
63
63
63
Market Capitalization
72
92
191

Working Capital

FRC

•

in mil. unless spec.
Dec'25
Mar'26
Jun'26
Total Current Assets
72
46
37
Cash, Cash Equivalents & STI
67
41
33
Accounts Receivable, Net
- -
- -
- -
Inventories
- -
- -
- -
Total Current Liabilities
21
17
27
Payables & Accruals
16
15
16
ST Debt
2
2
2
Deferred Revenue
- -
- -
10

Growth Rates

FRC

•

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
- -
-378.06%
-55.77%
Free Cash Flow
- -
68.47%
9.67%
Net Income, GAAP
- -
104.01%
2.96%
Sales/Revenue/Turnover
- -
- -
-14.17%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
16
- -
- -
- -
16
2025
- -
3
- -
11
14
2026
- -
- -
- -
- -
- -

Quarterly Earnings Per Share

FRC

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.06
-0.29
-0.35
- -
-1.32
2025
-0.35
-0.3
-0.35
- -
-1.28
2026
-0.37
-0.4
- -
- -
- -

Quarterly Dividends Per Share

FRC

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

CEO
Thomas Civik
Full Time Employees
56
Sector
Healthcare
Industry
Biotechnology
Address
321 Harrison Avenue Boston MA United States of America 02118
IPO Date
Oct 8, 2021
Business
Pyxis Oncology, Inc. (PYXS) is a clinical-stage biotechnology company that develops antibody-drug conjugates and immunotherapies targeting difficult-to-treat solid tumors. The company offers a pipeline of product candidates including PYX-201, a lead investigational ADC comprising human immunoglobulin G1 targeting extradomain-B fibronectin in Phase 1 trials for relapsed or refractory solid tumors such as head and neck squamous cell carcinoma; PYX-106, a Siglec-15-targeting monoclonal antibody in Phase 1 for advanced solid tumors; PYX-107, a CD40 agonist monoclonal antibody in Phase 2 for soft tissue sarcomas, esophageal and gastroesophageal junction cancers, and pancreatic ductal adenocarcinoma; PYX-203, an ADC licensed from Pfizer Inc.; and additional candidates leveraging its proprietary Flexible Antibody Conjugation Technology platform combined with the APXiMAB antibody-discovery platform. Pyxis Oncology, founded in 2018 and headquartered in Boston, Massachusetts, operates primarily in the United States with a focus on oncology therapeutics for patients with advanced cancers. Recent strategic developments include the 2023 acquisition of Apexigen, adding a validated Phase 2-ready antibody platform and expanding ADC capabilities while maintaining cash runway into 2026; in-licensing deals with Pfizer for ADC candidates like PYX-201 and PYX-203, and with Biosion USA for PYX-106; positive November 2024 Phase 1 data for PYX-201 showing 50% objective response rate in head and neck squamous cell carcinoma; and December 2024 portfolio prioritization to focus resources on PYX-201 monotherapy and combination trials, including with Keytruda in front-line settings, while deprioritizing PYX-106.

Company News

  • Pyxis Oncology (NASDAQ:PYXS) & Precigen (NASDAQ:PGEN) Head to Head Analysis

  • Pyxis Oncology: Better Runway Is Bullish For MICVO's Remaining R&D

  • Pyxis Oncology Announces Closing of Up to $282.6 Million Public Offering

  • Critical Survey: Pyxis Oncology (NASDAQ:PYXS) versus Inovio Pharmaceuticals (NASDAQ:INO)

  • Pyxis Oncology Announces Pricing of Up to $282.6 Million Public Offering

  • Pyxis Oncology Announces Proposed Public Offering

  • Critical Analysis: Pyxis Oncology (NASDAQ:PYXS) vs. ProKidney (NASDAQ:PROK)

  • Alumis (NASDAQ:ALMS) & Pyxis Oncology (NASDAQ:PYXS) Head-To-Head Review

  • Pyxis Oncology, Inc. (PYXS) Discusses MICVO Monotherapy Phase I Clinical Data in Head and Neck Squamous Cell Carcinoma Transcript

  • Pyxis Oncology Analyst Flags Key Safety Liabilities from Cancer Drug

  • Pyxis Oncology Announces Positive Updated Data from Phase 1 Monotherapy Study of Micvotabart Pelidotin (MICVO) in Second-Line and Beyond Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (2L+ R/M HNSCC)

  • Pyxis Oncology to Host Webcast to Present Updated Data from Phase 1 Monotherapy Study of Micvotabart Pelidotin (MICVO) in Second-Line and Beyond Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (2L+ R/M HNSCC)

  • Pyxis Oncology Appoints Thomas Civik Chief Executive Officer and Chairman of the Board

  • Pyxis Oncology to Participate in Upcoming Investor Conferences

  • Pyxis Oncology Reports Second Quarter 2026 Financial Results and Advances MICVO Toward Key 2026 Clinical Milestones

  • Financial Analysis: Pyxis Oncology (NASDAQ:PYXS) and GenSight Biologics (OTCMKTS:GSGTF)

  • Pyxis Oncology Announces Up to $114 Million Private Placement Financing to Advance MICVO Through Key Clinical Milestones

  • Pyxis Oncology Reports First Quarter 2026 Financial Results and Advances MICVO Toward Key 2026 Clinical Milestones

  • Pyxis Oncology to Participate in Upcoming Investor Conferences

  • Pyxis Oncology Appoints Nelson Azoulay as Chief Business Officer