TransCode Therapeutics, Inc.
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- TransCode Therapeutics, Inc. (NASDAQ:RNAZ) develops RNA-based therapeutics targeting metastatic cancer using its proprietary TTX nanoparticle delivery platform; lead candidate TTX-MC138 inhibits microRNA-10b, a master regulator of metastatic cell viability in breast, pancreatic, ovarian, colon, glioblastoma and other cancers; preclinical pipeline includes TTX-siPDL1, an siRNA-based modulator of programmed death-ligand 1; TTX-RIGA, an RNA-based agonist of retinoic acid-inducible gene I to activate innate immunity in the tumor microenvironment; TTX-CRISPR, a CRISPR/Cas9 platform for editing cancer-causing genes in tumor cells; TTX-mRNA, an mRNA platform for cancer vaccines eliciting cytotoxic immune responses; and TTX-siMYC, an RNA-based inhibitor of c-MYC oncogene. The company expanded its pipeline in October 2025 through acquisition of Polynoma LLC from CK Life Sciences, adding Phase 3-ready seviprotimut-L, a polyvalent shed antigen vaccine for adjuvant treatment of stage IIB/IIC melanoma; concurrent $25 million equity investment from CK Life Sciences subsidiary, comprising $20 million cash and $5 million note, to fund TTX-MC138 Phase 2 trial initiation; Dr. Philippe P. Calais, Pharm.D., appointed chief executive officer with Tom Fitzgerald transitioning to chief financial officer; CK Life Sciences to hold approximately 91% fully diluted ownership post-closing, valued at $165 million with up to $95 million contingent milestone payments. TransCode Therapeutics operates in the biotechnology sector focusing on oncology; targets patients with metastatic and high-risk early-stage cancers; maintains strategic collaboration with The University of Texas MD Anderson Cancer Center. Founded in 2016, the company is headquartered in Boston, Massachusetts.
TransCode Therapeutics, Inc. (RNAZ) Discusses Strategic, Scientific, and Clinical Updates With Focus on TTX-MC138 Phase 2a Trial in Colorectal Cancer Prepared Remarks Transcript
TransCode Therapeutics to Host R&D Webcast on June 18, 2026
TransCode Therapeutics Successfully Completes Phase 1a Clinical Trial, Reports Safety and Stabilization Data for TTX-MC138 in Metastatic Cancer
EXCLUSIVE: TransCode's RNA Therapeutic Achieves 64% Stable Disease Rate In Colorectal Cancer Phase 1 Study
TransCode Therapeutics Initiates Phase 2a Clinical Trial with TTX-MC138 in Patients with ctDNA Positive Colorectal Cancer
TransCode Therapeutics Appoints Dr. Anna Moore as Chair of Scientific Advisory Board; Announces Sponsored Research Agreement with Michigan State University
TransCode Therapeutics Enters into Agreements for up to $20 Million Flexible Financing, Extending Company's Runway into Late 2027/Early 2028
4D Molecular Therapeutics (NASDAQ:FDMT) versus TransCode Therapeutics (NASDAQ:RNAZ) Head-To-Head Contrast
Head-To-Head Comparison: Karyopharm Therapeutics (NASDAQ:KPTI) & TransCode Therapeutics (NASDAQ:RNAZ)
TransCode Secures Exclusive, Worldwide, Fully Paid-Up Royalty-Free License to Develop and Commercialize a Next-Generation Oncolytic Immunotherapy Platform in an All-Stock Transaction Underscoring the Company's Dedication to Improving the Lives of Cancer Patients
TransCode Therapeutics Announces Publication of Preclinical Testing of RIG-I Immunotherapeutic Candidate Supporting Further Development
TransCode Therapeutics and Quantum Leap Announce Submission of IND Amendment for Phase 2a Clinical Trial with TTX-MC138
TransCode Therapeutics Announces Publication of Preclinical Data Supporting Therapeutic Potential of TTX-MC138 in Glioblastoma
TransCode Therapeutics Expands Leadership with Appointment of Jack E. Stover to Board of Directors
TransCode Therapeutics and Quantum Leap Healthcare Collaborative Launch a Phase 2a dose-expansion trial with TTX-MC138, following positive readouts from TransCode's Phase 1 trial
TransCode Therapeutics (NASDAQ:RNAZ) Shares Up 0.9% – Here’s Why
TransCode Therapeutics Expands Executive Team with Appointment of Dr. Michel Janicot as Senior Development Officer
TransCode Therapeutics presents preliminary data from its completed Phase 1a study with TTX-MC138 in metastatic disease at ESMO
TransCode Therapeutics Appoints Dr. Phillip D. Zamore to Science Advisory Board
TransCode Therapeutics Successfully Completes Initial Dosing of Patients in Cohort 4 of Phase 1a Clinical Trial; No Dose Limiting Toxicities Reported