Spero Therapeutics, Inc.
NASDAQ Global SelectCapital Structure
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in mil. unless spec.Working Capital
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in mil. unless spec.Growth Rates
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in mil. unless spec.Quarterly Revenue
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in mil. unless spec.Quarterly Earnings Per Share
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in mil. unless spec.Quarterly Dividends Per Share
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in mil. unless spec.- CEO
- Esther Rajavelu
- Full Time Employees
- 32
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 675 Massachusetts Avenue Cambridge MA United States of America 02139
- IPO Date
- Nov 2, 2017
- CIK
- 0001701108
- Website
- sperotherapeutics.com
- Similar Companies
- Business
- Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company specializing in the development and commercialization of novel treatments for rare diseases and serious bacterial infections caused by multi-drug resistant (MDR) Gram-negative pathogens. The company's core product candidates include tebipenem HBr, an investigational oral carbapenem antibiotic targeting complicated urinary tract infections (cUTI) including acute pyelonephritis, intended as an effective outpatient oral therapy alternative to intravenous treatments; and SPR720, a prodrug antibiotic developed for the treatment of nontuberculous mycobacterial (NTM) pulmonary disease, which the company discontinued in 2025 following a review of clinical data. Spero also focuses on other pipeline programs addressing MDR bacterial infections through innovative mechanisms aimed at reducing virulence and persistence of pathogens such as Pseudomonas aeruginosa. Founded in 2014 and headquartered in Cambridge, Massachusetts, Spero Therapeutics operates primarily in the United States with strategic partnerships and licensing agreements extending its geographic reach. A significant recent development includes its collaboration with GlaxoSmithKline (GSK), which acquired exclusive rights outside certain Asian territories for tebipenem HBr in 2022, with plans to commercialize the product globally. In 2025, the Phase 3 PIVOT-PO trial for tebipenem HBr was stopped early due to meeting primary efficacy endpoints, demonstrating non-inferiority to intravenous imipenem-cilastatin in hospitalized patients with cUTI. This trial success positions tebipenem HBr for an anticipated FDA submission in the fourth quarter of 2025 and potential regulatory approval by the second half of 2026, marking a critical strategic milestone for Spero. The company has since discontinued development of SPR720 but continues to focus on advancing tebipenem HBr and its broader pipeline of treatments addressing antibiotic resistance challenges. Spero Therapeutics’ strategic direction emphasizes advancing oral antibiotic therapies for difficult-to-treat infections, leveraging partnerships for regulatory and commercial support while maintaining a pipeline of early-stage and clinical-stage assets targeting high unmet medical needs. The company is publicly traded under the ticker symbol SPRO on the NASDAQ and maintains a strong cash position to support its clinical development and operational activities. Its operational strategy combines proprietary research with collaborative development to drive innovation in anti-infective therapies. This description encompasses Spero Therapeutics’ current business focus, product portfolio including tebipenem HBr and discontinued SPR720, recent strategic partnership with GSK, clinical trial progress, and financial positioning as of late 2025. Sources confirm the Phase 3 trial achievements, partnership details, pipeline updates, and strategic shifts within the last two years.
Spero Therapeutics Announces First Quarter 2026 Operating Results and Provides Business Update
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Spero Therapeutics Announces Fourth Quarter and Full Year 2025 Operating Results and Provides a Business Update
Spero Therapeutics to Report Fourth Quarter and Full Year 2025 Financial Results and Provide Business Update on March 26, 2026
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Spero Announces NDA Resubmission of Tebipenem HBr by GSK to the FDA for the Treatment of Complicated Urinary Tract Infections, Including Pyelonephritis
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Spero Therapeutics Announces Third Quarter 2025 Operating Results and Provides a Business Update
Spero Therapeutics to Report Third Quarter 2025 Financial Results and Provide Business Update on November 13, 2025
PIVOT-PO Phase 3 Data Show Tebipenem HBr's Potential as the First Oral Carbapenem Antibiotic for Patients with Complicated Urinary Tract Infections (cUTIs)
Spero Therapeutics Announces Presentations on Tebipenem Hbr at IDWeek
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Spero Therapeutics, Inc. (SPRO) Q2 2025 Earnings Call Transcript
Spero Therapeutics Announces Second Quarter 2025 Operating Results and Provides a Business Update
Spero Therapeutics to Report Second Quarter 2025 Financial Results and Provide Business Update on Tuesday, August 12, 2025
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Squarepoint Ops LLC Buys Shares of 55,051 Spero Therapeutics, Inc. (NASDAQ:SPRO)