- CEO
- Søren Bregenholt
- Full Time Employees
- 11
- Sector
- Health technology
- Industry
- Biotechnology
- Address
- Medicon Village Lund SN Sweden 223 81
- IPO Date
- Nov 23, 2016
- Business
- Alligator Bioscience AB (publ) is a clinical-stage biotechnology company that develops tumor-directed immuno-oncology antibody drugs for cancer treatment. The company specializes in agonist mono- and bispecific antibodies targeting immune pathways such as CD40 and 4-1BB to activate the patient's immune system within the tumor microenvironment; its lead product candidate is mitazalimab, a CD40-targeting agonist antibody in preparation for Phase 3 trials in first-line metastatic pancreatic cancer following positive Phase 2 OPTIMIZE-1 results showing unprecedented 24-month survival outcomes; additional pipeline assets include ATOR-1017, a 4-1BB agonist monoclonal antibody in Phase 1 for solid tumors; ALG.APV-527, a 4-1BB x 5T4 bispecific T-cell engager co-developed with Aptevo Therapeutics in Phase 1 for solid metastatic tumors; ATOR-4066, a preclinical tumor-directed bispecific using the Neo-X-Prime platform; and early-stage candidates from proprietary platforms ALLIGATOR-GOLD (human antibody library), ALLIGATOR-FAB (scaffolded Fab library), FIND (molecular evolution technology), and RUBY (bispecific format). Alligator operates primarily in Sweden and Finland with global partnerships, targeting high-unmet-need solid tumors through early-stage drug development up to Phase 2 clinical trials. Founded in 2001 and headquartered in Lund, Sweden, the company maintains collaborations including a 2021 research and license agreement with Orion Corporation for RUBY-based bispecifics, a 2017 co-development pact with Aptevo for ALG.APV-527, and agreements with BioArctic, MacroGenics, Biotheus, and Abclon (via subsidiary Atlas Therapeutics) for antibody technologies and licensed programs like AC101 in Phase 2 by Shanghai Henlius; recent developments encompass a rights issue announced October 2025 for SEK 120 million to fund 6-9 months of operations into 2026, February 2025 top-line data validating the 900 µg/kg mitazalimab dose for Phase 3, an August 2025 R&D event highlighting the pipeline, peer-reviewed publication of ATOR-1017 clinical data in January 2025, FDA Orphan Drug Designation, and a January 2024 US patent for ATOR-4066.