Zai Lab Limited
NASDAQ Global MarketCapital Structure
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in mil. unless spec.Company Description
- CEO
- Ying Du
- Full Time Employees
- 1,784
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- Jinchuang Plaza Shanghai SH People's Republic of China 201210
- IPO Date
- Sep 20, 2017
- CIK
- 0001704292
- Website
- zailaboratory.com
- Similar Companies
- Business
- Zai Lab Limited is a commercial-stage biopharmaceutical company dedicated to discovering, developing, and commercializing transformative medicines for patients in areas of significant unmet medical need, particularly within oncology, autoimmune disorders, infectious diseases, and neuroscience. The company operates primarily in Mainland China and Hong Kong, with a growing global presence. Zai Lab's commercial portfolio features several innovative therapies. Zejula (niraparib) is a once-daily oral PARP 1/2 inhibitor approved for the maintenance treatment of adult patients with advanced ovarian, fallopian tube, or primary peritoneal cancer, including first-line and recurrent platinum-sensitive settings. Optune delivers Tumor Treating Fields, a non-invasive therapy for newly diagnosed and recurrent glioblastoma (GBM). NUZYRA (omadacycline) is a modern tetracycline-class antibiotic for the treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI). Qinlock (ripretinib) is a kinase inhibitor indicated for advanced gastrointestinal stromal tumors (GIST) in adult patients who have received prior treatments. More recently, XACDURO (sulbactam-durlobactam) received approval in China for hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) caused by susceptible Acinetobacter baumannii-calcoaceticus complex isolates. The company also commercializes VYVGART, an FcRn blocker for generalized myasthenia gravis (gMG) and chronic inflammatory demyelinating polyneuropathy (CIDP) in China, which significantly contributes to its revenue. The company maintains a robust and diverse pipeline of investigational therapies. This includes Odronextamab for various B-cell lymphomas and Repotrectinib (also known as AUGTYRO), a tyrosine kinase inhibitor targeting ROS1 and TRK fusions, with approvals in some markets and a key revenue driver for Zai Lab. Other pipeline assets feature Margetuximab for breast and gastroesophageal cancers, Adagrasib for KRAS-G12C-mutated solid tumors, and Bemarituzumab, which has shown promise in gastric and gastroesophageal junction cancer and received FDA Fast Track designation. Zai Lab is also advancing internal research and development programs, such as ZL-1102, a topical anti-IL-17A human nanobody in Phase 2 for chronic plaque psoriasis. Furthermore, KarXT (xanomeline-trospium), an oral M1/M4-preferring muscarinic agonist, is progressing for psychiatric and neurological conditions like schizophrenia, with a New Drug Application accepted in China. The pipeline also includes ZL-1310, a DLL3 antibody-drug conjugate for small cell lung cancer, which has received FDA Fast Track designation and is slated for a pivotal study in late 2025. Zai Lab's revenue model is largely driven by product sales from its commercialized therapies in China, supplemented by collaboration agreements that can include upfront payments, milestones, and royalties. The company, founded in 2013, has headquarters in Shanghai, China, and offices in the United States, pursuing a strategy of leveraging global partnerships to bring innovative medicines to patients in China and beyond, with a focus on addressing high unmet medical needs. Zai Lab reported a total revenue of $0.39 billion in 2024, with a projected path toward profitability by 2025.
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