Prime Medicine, Inc.

Prime Medicine, Inc.

PRME
Prime Medicine, Inc.US flagNASDAQ Global Market
3.70
USD
-0.01
- -
668.28MMarket Cap
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
0.07
- -
- -
- -
0.03
0.03
0.02
Basic EPS, GAAP
-0.05
-2.54
-4.19
-2.18
-1.65
-1.35
-1.09
Free Cash Flow per Basic Share
-0.09
-0.53
-4.36
-1.91
-1.1
-1.12
-0.91
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
0.02
-1.61
3.25
1.37
1.17
0.67
0.22
Tangible Book Value per Share
0.02
-1.61
3.25
1.37
1.17
0.67
0.22
Basic Weighted Avg Shares
72
72
34
91
119
149
172
Sales/Revenue/Turnover
5
- -
- -
- -
3
5
4
Operating Margin (%)
-17.89
- -
- -
- -
-6,787.36
-4,498.06
-4,824.94
Depreciation Expense
- -
1
2
5
6
7
7
Net Income, GAAP
-3
-165
-122
-198
-196
-201
-188
Effective Tax Rate (%)
- -
- -
- -
- -
- -
- -
- -
Profit Margin (%)
-65.45
- -
- -
- -
-6,566.61
-4,342.44
-4,613.11
Working Capital
34
213
270
87
174
144
65
LT Debt
- -
3
17
4
37
108
104
Total Equity
33
240
316
133
153
121
40
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
Return on Common Equity (%)
- -
- -
- -
-88.19
-136.88
-146.81
-373.29

Capital Structure

FRC

in mil. unless spec.
Dec'25
Mar'26
Jun'26
ST Debt
8
9
- -
LT Borrowings
- -
- -
- -
LT Finance Leases
108
106
104
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
181
181
181
Market Capitalization
626
629
667

Working Capital

FRC

in mil. unless spec.
Dec'25
Mar'26
Jun'26
Total Current Assets
181
138
97
Cash, Cash Equivalents & STI
178
135
47
Accounts Receivable, Net
- -
- -
- -
Inventories
- -
- -
- -
Total Current Liabilities
37
36
32
Payables & Accruals
12
16
- -
ST Debt
8
9
- -
Deferred Revenue
8
7
8

Growth Rates

FRC

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
- -
116.75%
-21.08%
Free Cash Flow
- -
165.22%
28.38%
Net Income, GAAP
- -
957.47%
2.69%
Sales/Revenue/Turnover
- -
- -
55.28%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
1
- -
- -
2
3
2025
1
1
1
1
5
2026
1
1
- -
- -
- -

Quarterly Earnings Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.44
-0.46
-0.44
- -
-1.65
2025
-0.4
-0.41
-0.32
- -
-1.35
2026
-0.28
-0.24
- -
- -
- -

Quarterly Dividends Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

CEO
Allan Reine
Full Time Employees
146
Sector
Healthcare
Industry
Biotechnology
Address
60 First Street Cambridge MA United States of America 02141
IPO Date
Oct 20, 2022
Business
Prime Medicine, Inc. (PRME) develops gene editing therapies using its proprietary Prime Editing platform, a next-generation technology that enables precise search-and-replace DNA modifications without double-strand breaks to treat genetic diseases across hematology, immunology and oncology, liver, and lung therapeutic areas. The company offers a pipeline of investigational programs including PM359, an ex vivo autologous hematopoietic stem cell therapy delivered via electroporation for p47phox chronic granulomatous disease (CGD) currently in Phase 1/2 trials under the Prime-0101 study and holding rare pediatric and orphan drug designations from the U.S. FDA; in vivo lipid nanoparticle (LNP)-delivered Prime Editors for Wilson's Disease and Alpha-1 antitrypsin deficiency (AATD), with PM647 nominated as the AATD development candidate in August 2025; LNP/AAV Prime Editors incorporating PASSIGE technology for cystic fibrosis; and ex vivo CAR-T cell products incorporating PASSIGE for immunology and oncology indications. Prime Medicine operates primarily in the United States, targeting patients with debilitating genetic disorders through one-time curative therapies. Founded in 2019 and headquartered in Cambridge, Massachusetts, the company recently entered a strategic license and broad collaboration agreement with Bristol Myers Squibb in September 2024 to develop and commercialize ex vivo T-cell Prime Editor products with up to $3.5 billion in potential value; secured up to $15 million from the Cystic Fibrosis Foundation in January 2024 to advance cystic fibrosis programs; appointed Matthew Hawryluk, Ph.D., M.B.A., as Chief Business Officer in November 2025 to bolster strategic partnerships; narrowed its pipeline from 18 to four core preclinical and clinical programs focused on high-value liver and lung diseases; and completed a financing round extending its cash runway while presenting new preclinical data for Wilson's Disease PM577 at the AASLD meeting in late 2025.

Company News

  • Prime Medicine to Participate in Upcoming Investor Conferences

  • BlackRock Inc. Acquires Shares of 9,602,041 Prime Medicine, Inc. $PRME

  • Prime Medicine: Soon In The Clinic

  • Prime Medicine, Inc. (PRME) Reports Q2 Loss, Misses Revenue Estimates

  • Prime Medicine, Inc. (PRME) May Report Negative Earnings: Know the Trend Ahead of Q2 Release

  • Prime Medicine Announces U.S. FDA Clearance of Investigational New Drug Application for PM577a in H1069Q-mutated Wilson Disease

  • Prime Medicine, Inc. $PRME Shares Sold by Amova Asset Management Americas Inc.

  • Prime Medicine Beats Beam Therapeutics In Patent Dispute - But Both Are Investable

  • Prime Medicine Secures Favorable Arbitration Ruling in Beam Therapeutics Case

  • Prime Medicine Announces Positive Resolution to Arbitration with Beam Therapeutics

  • Prime Medicine Receives U.S. FDA Regenerative Medicine Advanced Therapy (RMAT) Designation for PM359 for the Treatment of Chronic Granulomatous Disease (CGD)

  • Prime Medicine Announces New Zealand Clearance of Clinical Trial Application for PM577a in H1069Q-mutated Wilson Disease

  • Ocular Therapeutix vs. Prime Medicine: Which Healthcare Stock Is a Better Buy in 2026?

  • Prime Medicine's Prime Editing Is Worth The Risk

  • Prime Drink Group Announces Private Placement and Agreed Resolution with Creditors

  • Prime Medicine, Inc. (PRME) Presents at Goldman Sachs 47th Annual Global Healthcare Conference 2026 Prepared Remarks Transcript

  • Prime Medicine, Inc. (PRME) Presents at Jefferies Global Healthcare Conference 2026 Transcript

  • Prime Medicine to Present at Goldman Sachs 47th Annual Global Healthcare Conference

  • Prime Medicine to Present at Jefferies Global Healthcare Conference

  • Prime Medicine, Inc. (PRME) Reports Q1 Loss, Misses Revenue Estimates