Spyre Therapeutics, Inc.
NASDAQ Capital MarketCapital Structure
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in mil. unless spec.Working Capital
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in mil. unless spec.Growth Rates
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in mil. unless spec.Quarterly Revenue
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in mil. unless spec.Quarterly Earnings Per Share
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in mil. unless spec.Quarterly Dividends Per Share
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in mil. unless spec.- CEO
- Cameron Turtle
- Full Time Employees
- 112
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 221 Crescent Street Waltham MA United States of America 02453
- IPO Date
- Apr 7, 2016
- CIK
- 0001636282
- Website
- spyre.com
- Similar Companies
- Business
- Spyre Therapeutics, Inc. is a clinical-stage biotechnology firm dedicated to advancing novel therapeutic solutions for individuals afflicted with inflammatory bowel disease (IBD) and other immune-mediated conditions. The company's pipeline emphasizes developing long-acting monoclonal antibodies through advanced antibody engineering and strategic combination approaches. Its leading investigational candidate, SPY001, is a human monoclonal immunoglobulin G1 antibody engineered to specifically target the α4β7 integrin pathway for treating IBD, encompassing ulcerative colitis and Crohn's disease. Recent positive interim Phase 1 data for SPY001 showcased a favorable safety profile and an extended half-life exceeding 90 days, potentially enabling quarterly or even semi-annual subcutaneous dosing, significantly less frequent than existing therapies. Spyre intends to commence a Phase 2 platform trial for SPY001 in ulcerative colitis in mid-2025. Furthermore, Spyre is progressing SPY002, comprising human monoclonal antibody candidates designed to interact with tumor necrosis factor-like ligand 1A (TL1A), which has also shown potential for quarterly dosing with a half-life over three times longer than first-generation alternatives. The company's portfolio also includes SPY003, an anti-IL-23 monoclonal antibody, with first-in-human dosing expected in early 2025 and the potential for quarterly or twice-yearly maintenance dosing. Early-stage studies also explore combination therapies, such as SPY120 (combining SPY001 and SPY002), SPY130 (combining anti-α4β7 and anti-IL-23), and SPY230 (combining anti-TL1A and anti-IL-23), which aim to enhance efficacy and convenience. The company is expanding its SPY002 program to include rheumatoid arthritis, with a Phase 2 trial anticipated to start in mid-2025. Originally incorporated in 2013, the company operated as Aeglea BioTherapeutics, Inc. before adopting the name Spyre Therapeutics, Inc. in November 2023. It maintains its operations in Waltham, Massachusetts. Spyre Therapeutics maintains a robust financial position, with cash and marketable securities anticipated to provide a runway into the second half of 2028.
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