Upstream Bio, Inc.

UPB

UPBUpstream Bio, Inc. US flag

NASDAQ Global Select

3.03

USD

+0.23

- -

165.84MMarket Cap

Profitability (USD)

Profitability Ratios API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Return on Common Equity (%)	- -	- -	- -	-35.43
Return on Assets (%)	- -	-30.27	-20.97	-34.34
Return on Capital (%)	- -	- -	- -	- -
Return on Invested Capital (%)	- -	- -	- -	- -
Gross Margin (%)	100	100	100	100
EBITDA Margin (%)	-1,972.11	-1,682.94	-3,277.43	-5,612.23
Operating Margin (%)	-1,972.69	-1,685.46	-3,281.18	-5,618.82
Incremental Operating Margin (%)	- -	- -	- -	- -
Pretax Margin (%)	-1,969.31	-862.9	-2,650.04	-5,026.03
Profit Margin (%)	-1,969.31	-862.9	-2,650.04	-5,026.03
Net Income to Common Margin (%)	-1,969.31	-1,607.35	-3,223.42	-5,026.03
Effective Tax Rate (%)	- -	- -	- -	- -
Dvd Payout Ratio (%)	- -	46.32	17.79	- -
Sustainable Growth Rate (%)	- -	- -	- -	-35.43

Credit (USD)

Credit Ratios API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Total Debt	- -	- -	2	1
ST Debt	- -	- -	1	1
LT Debt	- -	- -	1	1
Total Debt/EBITDA	- -	- -	-0.02	-0.01
Net Debt/EBITDA	0.71	0.64	4.2	0.63
Total Debt/EBIT	- -	- -	-0.02	-0.01
Net Debt/EBIT	0.71	0.64	4.19	0.63
EBITDA to Interest Expense	- -	- -	- -	- -
EBITDA-CapEx/Interest Expense	- -	- -	- -	- -
EBIT to Interest Expense	- -	- -	- -	- -
Interest Expense	- -	- -	- -	- -
Common Equity/Total Assets	-574.49	-105.06	97.54	96.04
Long-Term Debt/Equity (%)	- -	- -	0.24	0.16
Long-Term Debt/Capital (%)	-0.01	- -	0.24	0.16
Long-Term Debt/Total Assets (%)	0.04	- -	0.23	0.16
Total Debt/Equity (%)	-0.09	-0.04	0.39	0.37
Total Debt/Capital (%)	-0.09	-0.04	0.39	0.37
Total Debt/Total Assets (%)	0.51	0.04	0.38	0.36
Net Debt to Equity	16.06	20.98	-69.36	-29.9
Net Debt/Capital (%)	13.85	17.35	-223.53	-42.42
EBITDA	-24	-40	-78	-160
EBITDA-CapEx	-24	-40	-78	-160
Operating Income (Loss)	-24	-40	-78	-160

Liquidity (USD)

Liquidity Ratios API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Cash Ratio	3.51	16.85	43.82	25.39
Current Ratio	3.77	17.96	44.63	26.15
Quick Ratio	3.6	16.89	43.93	25.56
CFO/Avg Current Liab	- -	-6.67	-6.86	-11.02
Common Equity/Total Assets	-574.49	-105.06	97.54	96.04
Long-Term Debt/Equity (%)	- -	- -	0.24	0.16
Long-Term Debt/Capital (%)	-0.01	- -	0.24	0.16
Long-Term Debt/Total Assets (%)	0.04	- -	0.23	0.16
Total Debt/Equity (%)	-0.09	-0.04	0.39	0.37
Total Debt/Capital (%)	-0.09	-0.04	0.39	0.37
Total Debt/Total Assets (%)	0.51	0.04	0.38	0.36
CFO/Total Liabilities	-15.26	-15.78	-498.63	-951.9
CFO/CapEx	-231.96	-263.38	-115.8	-807.73
Altman's Z-Score	-11.47	-1.51	44.64	61.44

Working Capital (USD)

Working Capital Ratios API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Accounts Receivable Turnover	- -	9.33	6.67	4.46
Days Sales Outstanding	- -	39.11	54.75	81.91
Inventory Turnover	- -	- -	- -	- -
Days Inventory Outstanding	- -	- -	- -	- -
Accounts Payable Turnover	- -	- -	- -	- -
Accounts Payable Turnover Days	- -	- -	- -	- -
Cash Conversion Cycle	- -	- -	- -	- -
Inventory to Cash Days	- -	- -	- -	- -
Inventories	- -	- -	- -	- -
Raw Materials	- -	- -	- -	- -
Work In Process	- -	- -	- -	- -
Finished Goods	- -	- -	- -	- -
Other Inventory	- -	- -	- -	- -

Enterprise Value (USD)

Enterprise Value API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Market Capitalization	- -	- -	881	1,473
- Cash & Cash Equivalents	17	26	326	102
+ Preferred Equity and Hybrid Capital	- -	- -	- -	- -
+ Minority/Non Controlling Interest	- -	- -	- -	- -
+ Total Debt	- -	- -	2	1
Enterprise Value	-17	-110	413	1,132
Total Capital	-106	-123	472	341
Total Debt/Capital (%)	-0.09	-0.04	0.39	0.37
Total Debt / EV	-0.01	- -	- -	- -
EV/Sales	- -	- -	174.1	396.75
EV/EBITDA	- -	- -	- -	- -
EV/EBIT	- -	- -	- -	- -
EV/Cash Flow to Firm	- -	- -	- -	- -
EV/Free Cash Flow to Firm	- -	- -	- -	- -
Diluted Market Cap	- -	- -	881	1,473
Diluted Enterprise Value	-17	-26	557	1,372
EV per Share	- -	- -	7.7	20.88
TTM Sales	1	2	2	3
TTM EBITDA	-24	-40	-78	-160
TTM Operating Income	-24	-40	-78	-160
TTM Cash Flow to Firm	-19	-38	-59	-133
TTM Free Cash Flow to Firm	-19	-38	-59	-133

Multiples (USD)

Valuation Multiples API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Price/Free Cash Flow	- -	- -	-15.02	-11.06
EV/EBIT	- -	- -	- -	- -
Enterprise Value	-17	-110	413	1,132
Low Price	- -	- -	14.97	5.14
EV/Sales	- -	- -	174.1	396.75
EV/EBITDA	- -	- -	- -	- -
Price/Earnings	- -	- -	- -	- -
Price/Earnings Average	- -	- -	-15.67	-5.65
Price/Earnings High	- -	- -	-20.67	-12.48
Price/Earnings Low	- -	- -	-10.5	-1.94
Price/Book Value	- -	- -	1.88	4.33
Price/Book Value Average	- -	- -	2.55	2.38
Price/Book Value High	- -	- -	3.36	5.27
Price/Book Value Low	- -	- -	1.71	0.82
Price/Tangible Book Value	- -	- -	1.88	4.33
Price/Tangible Book Value Average	- -	- -	2.55	2.38
Price/Tangible Book Value High	- -	- -	3.36	5.27
Price/Tangible Book Value Low	- -	- -	1.71	0.82
Price/Sales	- -	- -	371.83	515.96
Price/Sales Average	- -	- -	505.02	283.77
Price/Sales High	- -	- -	666.31	627.14
Price/Sales Low	- -	- -	338.58	97.68
Price/Cash Flow	- -	- -	-14.89	-11.05
Price/Cash Flow Average	- -	- -	-20.23	-6.08
Price/Cash Flow High	- -	- -	-26.69	-13.43
Price/Cash Flow Low	- -	- -	-13.56	-2.09
Price/Free Cash Flow Average	- -	- -	-20.4	-6.08
Price/Free Cash Flow High	- -	- -	-26.92	-13.45
Price/Free Cash Flow Low	- -	- -	-13.68	-2.09
EV/Sales Average	- -	- -	368.28	248.62
EV/Sales High	- -	- -	529.58	591.99
EV/Sales Low	- -	- -	201.85	62.53
EV/EBITDA Average	0.71	0.64	-11.24	-4.43
EV/EBITDA High	0.71	0.64	-16.16	-10.55
EV/EBITDA Low	0.71	0.64	-6.16	-1.11
EV/EBIT Average	0.71	0.64	-11.22	-4.42
EV/EBIT High	0.71	0.64	-16.14	-10.54
EV/EBIT Low	0.71	0.64	-6.15	-1.11
Last Price	- -	- -	16.44	27.15
High Price	- -	- -	29.46	33
Enterprise Value Average	-17	-26	873	710
Enterprise Value High	-17	-26	1,255	1,690
Enterprise Value Low	-17	-26	478	178

Profitability (USD)

Profitability Ratios API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Return on Common Equity (%)	- -	- -	- -	-35.43
Return on Assets (%)	- -	-30.27	-20.97	-34.34
Return on Capital (%)	- -	- -	- -	- -
Return on Invested Capital (%)	- -	- -	- -	- -
Gross Margin (%)	100	100	100	100
EBITDA Margin (%)	-1,972.11	-1,682.94	-3,277.43	-5,612.23
Operating Margin (%)	-1,972.69	-1,685.46	-3,281.18	-5,618.82
Incremental Operating Margin (%)	- -	- -	- -	- -
Pretax Margin (%)	-1,969.31	-862.9	-2,650.04	-5,026.03
Profit Margin (%)	-1,969.31	-862.9	-2,650.04	-5,026.03
Net Income to Common Margin (%)	-1,969.31	-1,607.35	-3,223.42	-5,026.03
Effective Tax Rate (%)	- -	- -	- -	- -
Dvd Payout Ratio (%)	- -	46.32	17.79	- -
Sustainable Growth Rate (%)	- -	- -	- -	-35.43

Credit (USD)

Credit Ratios API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Total Debt	- -	- -	2	1
ST Debt	- -	- -	1	1
LT Debt	- -	- -	1	1
Total Debt/EBITDA	- -	- -	-0.02	-0.01
Net Debt/EBITDA	0.71	0.64	4.2	0.63
Total Debt/EBIT	- -	- -	-0.02	-0.01
Net Debt/EBIT	0.71	0.64	4.19	0.63
EBITDA to Interest Expense	- -	- -	- -	- -
EBITDA-CapEx/Interest Expense	- -	- -	- -	- -
EBIT to Interest Expense	- -	- -	- -	- -
Interest Expense	- -	- -	- -	- -
Common Equity/Total Assets	-574.49	-105.06	97.54	96.04
Long-Term Debt/Equity (%)	- -	- -	0.24	0.16
Long-Term Debt/Capital (%)	-0.01	- -	0.24	0.16
Long-Term Debt/Total Assets (%)	0.04	- -	0.23	0.16
Total Debt/Equity (%)	-0.09	-0.04	0.39	0.37
Total Debt/Capital (%)	-0.09	-0.04	0.39	0.37
Total Debt/Total Assets (%)	0.51	0.04	0.38	0.36
Net Debt to Equity	16.06	20.98	-69.36	-29.9
Net Debt/Capital (%)	13.85	17.35	-223.53	-42.42
EBITDA	-24	-40	-78	-160
EBITDA-CapEx	-24	-40	-78	-160
Operating Income (Loss)	-24	-40	-78	-160

Liquidity (USD)

Liquidity Ratios API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Cash Ratio	3.51	16.85	43.82	25.39
Current Ratio	3.77	17.96	44.63	26.15
Quick Ratio	3.6	16.89	43.93	25.56
CFO/Avg Current Liab	- -	-6.67	-6.86	-11.02
Common Equity/Total Assets	-574.49	-105.06	97.54	96.04
Long-Term Debt/Equity (%)	- -	- -	0.24	0.16
Long-Term Debt/Capital (%)	-0.01	- -	0.24	0.16
Long-Term Debt/Total Assets (%)	0.04	- -	0.23	0.16
Total Debt/Equity (%)	-0.09	-0.04	0.39	0.37
Total Debt/Capital (%)	-0.09	-0.04	0.39	0.37
Total Debt/Total Assets (%)	0.51	0.04	0.38	0.36
CFO/Total Liabilities	-15.26	-15.78	-498.63	-951.9
CFO/CapEx	-231.96	-263.38	-115.8	-807.73
Altman's Z-Score	-11.47	-1.51	44.64	61.44

Working Capital (USD)

Working Capital Ratios API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Accounts Receivable Turnover	- -	9.33	6.67	4.46
Days Sales Outstanding	- -	39.11	54.75	81.91
Inventory Turnover	- -	- -	- -	- -
Days Inventory Outstanding	- -	- -	- -	- -
Accounts Payable Turnover	- -	- -	- -	- -
Accounts Payable Turnover Days	- -	- -	- -	- -
Cash Conversion Cycle	- -	- -	- -	- -
Inventory to Cash Days	- -	- -	- -	- -
Inventories	- -	- -	- -	- -
Raw Materials	- -	- -	- -	- -
Work In Process	- -	- -	- -	- -
Finished Goods	- -	- -	- -	- -
Other Inventory	- -	- -	- -	- -

Enterprise Value (USD)

Enterprise Value API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Market Capitalization	- -	- -	881	1,473
- Cash & Cash Equivalents	17	26	326	102
+ Preferred Equity and Hybrid Capital	- -	- -	- -	- -
+ Minority/Non Controlling Interest	- -	- -	- -	- -
+ Total Debt	- -	- -	2	1
Enterprise Value	-17	-110	413	1,132
Total Capital	-106	-123	472	341
Total Debt/Capital (%)	-0.09	-0.04	0.39	0.37
Total Debt / EV	-0.01	- -	- -	- -
EV/Sales	- -	- -	174.1	396.75
EV/EBITDA	- -	- -	- -	- -
EV/EBIT	- -	- -	- -	- -
EV/Cash Flow to Firm	- -	- -	- -	- -
EV/Free Cash Flow to Firm	- -	- -	- -	- -
Diluted Market Cap	- -	- -	881	1,473
Diluted Enterprise Value	-17	-26	557	1,372
EV per Share	- -	- -	7.7	20.88
TTM Sales	1	2	2	3
TTM EBITDA	-24	-40	-78	-160
TTM Operating Income	-24	-40	-78	-160
TTM Cash Flow to Firm	-19	-38	-59	-133
TTM Free Cash Flow to Firm	-19	-38	-59	-133

Multiples (USD)

Valuation Multiples API ChatGPT

	2022 Y	2023 Y	2024 Y	2025 Y
As of date	12/31/2022	12/31/2023	12/31/2024	12/31/2025

Price/Free Cash Flow	- -	- -	-15.02	-11.06
EV/EBIT	- -	- -	- -	- -
Enterprise Value	-17	-110	413	1,132
Low Price	- -	- -	14.97	5.14
EV/Sales	- -	- -	174.1	396.75
EV/EBITDA	- -	- -	- -	- -
Price/Earnings	- -	- -	- -	- -
Price/Earnings Average	- -	- -	-15.67	-5.65
Price/Earnings High	- -	- -	-20.67	-12.48
Price/Earnings Low	- -	- -	-10.5	-1.94
Price/Book Value	- -	- -	1.88	4.33
Price/Book Value Average	- -	- -	2.55	2.38
Price/Book Value High	- -	- -	3.36	5.27
Price/Book Value Low	- -	- -	1.71	0.82
Price/Tangible Book Value	- -	- -	1.88	4.33
Price/Tangible Book Value Average	- -	- -	2.55	2.38
Price/Tangible Book Value High	- -	- -	3.36	5.27
Price/Tangible Book Value Low	- -	- -	1.71	0.82
Price/Sales	- -	- -	371.83	515.96
Price/Sales Average	- -	- -	505.02	283.77
Price/Sales High	- -	- -	666.31	627.14
Price/Sales Low	- -	- -	338.58	97.68
Price/Cash Flow	- -	- -	-14.89	-11.05
Price/Cash Flow Average	- -	- -	-20.23	-6.08
Price/Cash Flow High	- -	- -	-26.69	-13.43
Price/Cash Flow Low	- -	- -	-13.56	-2.09
Price/Free Cash Flow Average	- -	- -	-20.4	-6.08
Price/Free Cash Flow High	- -	- -	-26.92	-13.45
Price/Free Cash Flow Low	- -	- -	-13.68	-2.09
EV/Sales Average	- -	- -	368.28	248.62
EV/Sales High	- -	- -	529.58	591.99
EV/Sales Low	- -	- -	201.85	62.53
EV/EBITDA Average	0.71	0.64	-11.24	-4.43
EV/EBITDA High	0.71	0.64	-16.16	-10.55
EV/EBITDA Low	0.71	0.64	-6.16	-1.11
EV/EBIT Average	0.71	0.64	-11.22	-4.42
EV/EBIT High	0.71	0.64	-16.14	-10.54
EV/EBIT Low	0.71	0.64	-6.15	-1.11
Last Price	- -	- -	16.44	27.15
High Price	- -	- -	29.46	33
Enterprise Value Average	-17	-26	873	710
Enterprise Value High	-17	-26	1,255	1,690
Enterprise Value Low	-17	-26	478	178

Shares Outstanding	51	51	54	54
Diluted Weighted Avg Shares	36	36	54	54
Basic Weighted Avg Shares	36	36	54	54
Revenue per Share	0.03	0.07	0.04	0.05
EBITDA per Share	-0.66	-1.1	-1.45	-2.95
Operating Income per Share	-0.66	-1.1	-1.45	-2.96
Basic EPS, GAAP	-0.66	-1.05	-1.43	-2.64
Basic EPS from Cont Ops	-0.66	-0.57	-1.17	-2.64
Diluted EPS, GAAP	-0.66	-1.05	-1.43	-2.64
Diluted EPS from Cont Ops	-0.66	-0.57	-1.17	-2.64
Dividend per Share	- -	- -	- -	- -
Cash Flow per Share	-0.52	-1.04	-1.1	-2.46
Free Cash Flow per Basic Share	-0.53	-1.05	-1.11	-2.46
Cash & Equivalents per Share	0.33	2.14	8.78	6.3
Book Value per Share	-2.07	-2.4	8.77	6.26
Tangible Book Value per Share	-2.07	-2.4	8.77	6.26

Upstream Bio, Inc.

Profitability (USD)

Credit (USD)

Liquidity (USD)

Working Capital (USD)

Enterprise Value (USD)

Multiples (USD)

Profitability (USD)

Credit (USD)

Liquidity (USD)

Working Capital (USD)

Enterprise Value (USD)

Multiples (USD)

Per Share Data Items (USD)